Difference between revisions of "Urothelium"

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Urothelium (view source)

Revision as of 01:26, 28 November 2012

61 bytes removed ,  01:26, 28 November 2012
→‎Papillary urothelial lesions: redo
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Urothelial cells in papillae - benign/premalignant/cancerous:<ref>{{Ref GUP|166-175}}</ref><ref name=Ref_WMSP310>{{Ref WMSP|310}}</ref>
Urothelial cells in papillae - benign/premalignant/cancerous:<ref>{{Ref GUP|166-175}}</ref><ref name=Ref_WMSP310>{{Ref WMSP|310}}</ref>
{| class="wikitable"
{| class="wikitable"
|
| Diagnosis
| papillae features
| papillae branching
| papillae fusion
| nuclear size
| mitoses
| DDx
| IHC
| Other
| Key feature
|-
| '''Papilloma'''
| '''Papilloma'''
| '''PUNLMP'''
| '''fat papillae''', <br>'''thick FV core'''
| '''low grade PUCC'''
| rare
| '''high grade PUCC'''
| none
| normal (2x lymphocyte)
| very rare basal
| PUNLMP, low gr. PUCC
| p53-, CK20+ umbrella cells
| cytologically normal
| normal cells,<br>fat papillae
|-
|-
| papillae features
| '''PUNLMP'''
| '''fat papillae''', <br>'''thick FV core'''
| '''slender FV core'''
| '''slender FV core'''
| uncommon
| slender FV core, <br>'''thick epithelium'''
| rare
| mixed population
| '''enlarged - uniform'''
| rare basal only
| papilloma, low gr.
| CK20+ umbrella
| low cellular density (@ low power) vs. low gr.<ref>GAG. 26 February 2009.</ref>
| uniformly enlarged cell pop., <br>slender papillae
|-
|-
| papillae branching
| '''low grade PUCC'''
| rare
| slender FV core, <br>'''thick epithelium'''
| uncommon
| frequent
| frequent
| some
| common
| '''enlarged with variation'''
| infreq., usually basal
| PUNLMP, high gr.
| -/+ p53, CK20+ umbrella
| +/- small nucleoli
| nuc. pleomorphism, <br> thick epithelium
|-
|-
| papillae fusion
| '''high grade PUCC'''
| none
| mixed population
| rare
| common
| some
| common
| common
|-
| nuclear size
| normal (2x lymphocyte) |
| '''enlarged - uniform'''
| '''enlarged with variation'''
| '''4-5x lymphocyte,'''<br>'''marked pleomorphism'''
| '''4-5x lymphocyte,'''<br>'''marked pleomorphism'''
|-
| common, everywhere
| mitoses
| low gr., invasive UCC
| very rare basal
| '''diffuse CK20+''', p53+ in 50%
| rare basal only
| infreq., usually basal
| common, everywhere
|-
| DDx
| PUNLMP, low gr. PUCC
| papilloma, low gr.
| PUNLMP, high gr.
| low gr., invasive UCC
|-
|IHC
| p53-, CK20+ umbrella cells
| CK20+ umbrella
| -/+ p53, CK20+ umbrella
| '''diffuse CK20+''', p53+ in 50%
|-
|Other
| cytologically normal
| low cellular density (@ low power) vs. low gr.<ref>GAG. 26 February 2009.</ref>
| +/- small nucleoli
| nucleoli prominent
| nucleoli prominent
|-
|Key feature
| normal cells,<br>fat papillae
| uniformly enlarged cell pop., <br>slender papillae
| nuc. pleomorphism, <br> thick epithelium
| marked nuclear pleomorphism
| marked nuclear pleomorphism
|-
|-
Michael
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