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Difference between revisions of "Uterine cervix"
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→Clear cell carcinoma of the uterine cervix
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Note: | Note: | ||
*[[HPV]] does '''not''' appear to be important in the oncogenesis.<ref name=pmid21620450>{{Cite journal | last1 = Kocken | first1 = M. | last2 = Baalbergen | first2 = A. | last3 = Snijders | first3 = PJ. | last4 = Bulten | first4 = J. | last5 = Quint | first5 = WG. | last6 = Smedts | first6 = F. | last7 = Meijer | first7 = CJ. | last8 = Helmerhorst | first8 = TJ. | title = High-risk human papillomavirus seems not involved in DES-related and of limited importance in nonDES related clear-cell carcinoma of the cervix. | journal = Gynecol Oncol | volume = 122 | issue = 2 | pages = 297-302 | month = Aug | year = 2011 | doi = 10.1016/j.ygyno.2011.05.002 | PMID = 21620450 }}</ref> | *[[HPV]] does '''not''' appear to be important in the oncogenesis.<ref name=pmid21620450>{{Cite journal | last1 = Kocken | first1 = M. | last2 = Baalbergen | first2 = A. | last3 = Snijders | first3 = PJ. | last4 = Bulten | first4 = J. | last5 = Quint | first5 = WG. | last6 = Smedts | first6 = F. | last7 = Meijer | first7 = CJ. | last8 = Helmerhorst | first8 = TJ. | title = High-risk human papillomavirus seems not involved in DES-related and of limited importance in nonDES related clear-cell carcinoma of the cervix. | journal = Gynecol Oncol | volume = 122 | issue = 2 | pages = 297-302 | month = Aug | year = 2011 | doi = 10.1016/j.ygyno.2011.05.002 | PMID = 21620450 }}</ref> | ||
===Microscopic=== | ===Microscopic=== | ||
Features: | Features: | ||
*Like [[clear cell carcinoma]] elsewhere: | *Like [[clear cell carcinoma]] elsewhere: | ||
** | **Clear cytoplasm - '''key feature'''. | ||
***May be absent! | |||
**Cells have large free/luminal surface area (hobnailing pattern) and small non-free surface. | **Cells have large free/luminal surface area (hobnailing pattern) and small non-free surface. | ||
**Moderate-to-severe [[nuclear pleomorphism]]. | **Moderate-to-severe [[nuclear pleomorphism]]. | ||
DDx: | DDx: | ||
*[[Clear cell carcinoma of the endometrium]]. | *[[Clear cell carcinoma of the endometrium]] - diagnosis based on clinico-radiologic correlation (IHC & histology not useful).<ref name=pmid22885379>{{Cite journal | last1 = Offman | first1 = SL. | last2 = Longacre | first2 = TA. | title = Clear cell carcinoma of the female genital tract (not everything is as clear as it seems). | journal = Adv Anat Pathol | volume = 19 | issue = 5 | pages = 296-312 | month = Sep | year = 2012 | doi = 10.1097/PAP.0b013e31826663b1 | PMID = 22885379 }}</ref> | ||
*[[Serous carcinoma of the endometrium]]. | *[[Serous carcinoma of the endometrium]]. | ||
*Serous carcinoma of the cervix. | *Serous carcinoma of the cervix. | ||