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Difference between revisions of "Malignant melanoma"
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→IHC: more, subdivide
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(→IHC: more, subdivide) |
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==[[IHC]]== | ==[[IHC]]== | ||
Standard panel | ===Standard panel=== | ||
#S100 +ve. | #S100 +ve. | ||
#*Negative staining pretty much excludes the diagnosis. | #*Negative staining pretty much excludes the diagnosis. | ||
#HMB-45 +ve -- esp. deep. | #HMB-45 +ve -- esp. deep. | ||
#Melan A (MART-1) +ve. | #Melan A (MART-1) +ve. | ||
Notes: | Notes: | ||
*The standard panel above (S100, HMB-45, MART-1) is also positive in other lesions, e.g. ''[[cellular blue nevus]]''. | *The standard panel above (S100, HMB-45, MART-1) is also positive in other lesions, e.g. ''[[cellular blue nevus]]''. | ||
===Threshold panel=== | |||
When one it sure it is melanocyte... but unsure it is melanoma: | |||
*HMB-45 +ve deep. | |||
**In benign lesions it deep (mature) melanocytes are negative. | |||
*Ki-67. | |||
===Others=== | |||
*SOX10 +ve -- useful for differentiate from excision scar.<ref name=pmid20653825>{{cite journal |author=Ramos-Herberth FI, Karamchandani J, Kim J, Dadras SS |title=SOX10 immunostaining distinguishes desmoplastic melanoma from excision scar |journal=J. Cutan. Pathol. |volume=37 |issue=9 |pages=944–52 |year=2010 |month=September |pmid=20653825 |doi=10.1111/j.1600-0560.2010.01568.x |url=}}</ref> | |||
**SOX-10 = pan-schwannian and melanocytic marker. | |||
==See also== | ==See also== | ||