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Difference between revisions of "Fibroblastic/myofibroblastic tumours"
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Fibroblastic/myofibroblastic tumours (view source)
Revision as of 19:48, 10 September 2012
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*Beta-catenin +ve - '''important'''. | *Beta-catenin +ve - '''important'''. | ||
*SMA +ve ~50% of lesions. | *SMA +ve ~50% of lesions. | ||
==Lipofibromatosis== | ==Lipofibromatosis== | ||
| Line 348: | Line 324: | ||
===Molecular=== | ===Molecular=== | ||
*ALK rearrangements.<ref name=pmid21297584/> | *ALK rearrangements.<ref name=pmid21297584/> | ||
==Low-grade myofibroblastic sarcoma== | |||
===General=== | |||
*Rare ~ 100 cases in the literature. | |||
*Usu. oral cavity or extremities.<ref name=pmid21868549/> | |||
===Microscopic=== | |||
Features: | |||
*Spindle cells in the storiform pattern<ref name=pmid21868549/> ''or'' in fasicles. | |||
*Rare mitoses. | |||
Images: | |||
*[http://path.upmc.edu/cases/case673.html Low-grade myofibroblastic sarcoma - several images (upmc.edu)]. | |||
DDx: | |||
*Atypical [[leiomyoma]]. | |||
*[[GIST]]. | |||
*[[Leiomyosarcoma]]. | |||
===IHC=== | |||
*SMA +ve. | |||
*CD34 -ve. | |||
*CD117 -ve.<ref name=pmid21868549/> | |||
*H-caldesmon -ve.<ref name=pmid21868549>{{Cite journal | last1 = Miyazawa | first1 = M. | last2 = Naritaka | first2 = Y. | last3 = Miyaki | first3 = A. | last4 = Asaka | first4 = S. | last5 = Isohata | first5 = N. | last6 = Yamaguchi | first6 = K. | last7 = Murayama | first7 = M. | last8 = Shimakawa | first8 = T. | last9 = Katsube | first9 = T. | title = A low-grade myofibroblastic sarcoma in the abdominal cavity. | journal = Anticancer Res | volume = 31 | issue = 9 | pages = 2989-94 | month = Sep | year = 2011 | doi = | PMID = }}</ref> | |||
==Congenital-infantile fibrosarcoma== | ==Congenital-infantile fibrosarcoma== | ||