Difference between revisions of "An introduction to gynecologic pathology"

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=Introduction to gynecologic tumours=
=Introduction to gynecologic tumours=
'''Where to start when considering a malignant (epithelial) tumour of the gynecologic tract:'''
Where to start when considering a malignant (epithelial) tumour of the gynecologic tract:
{| class="wikitable"
|
| '''Serous'''
| '''Endometrioid''' 
| '''Mucinous'''
|-
|Characteristics
| cilia, columnar cells<br>[[psammoma bodies]], papillary arch.
| gland forming, endometrium-like
| mucinous glands, colon-like
|-
|Differentiators
| cilia, psammoma bodies
| squamous metaplasia
| mucin, lack of [[necrosis]]
|-
|Associations
| atrophy
| endometriosis, endometrial hyperplasia
| (?)
|-
|Typical age
| usually 60s+
| 40-60
| varies (?)
|-
|Grade
| typically high grade
| typically low grade
| often low
|-
|IHC
| p53+ diffuse, WT-1 +ve, D2-40 +ve, CA-125 +ve
| WT-1 -ve
| CK7 +ve, CK20 +ve (others CK7 +ve, CK20 -ve)
|-
|Main DDx
| poorly diff. endometrioid 
| serous |
| metastatic tumour (usually GI)
|-
|}
 
{| class="wikitable sortable"
{| class="wikitable sortable"
!Type
!Type
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