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| =Introduction to gynecologic tumours= | | =Introduction to gynecologic tumours= |
| '''Where to start when considering a malignant (epithelial) tumour of the gynecologic tract:'''
| | Where to start when considering a malignant (epithelial) tumour of the gynecologic tract: |
| {| class="wikitable"
| |
| |
| |
| | '''Serous'''
| |
| | '''Endometrioid'''
| |
| | '''Mucinous'''
| |
| |-
| |
| |Characteristics
| |
| | cilia, columnar cells<br>[[psammoma bodies]], papillary arch.
| |
| | gland forming, endometrium-like
| |
| | mucinous glands, colon-like
| |
| |-
| |
| |Differentiators
| |
| | cilia, psammoma bodies
| |
| | squamous metaplasia
| |
| | mucin, lack of [[necrosis]]
| |
| |-
| |
| |Associations
| |
| | atrophy
| |
| | endometriosis, endometrial hyperplasia
| |
| | (?)
| |
| |-
| |
| |Typical age
| |
| | usually 60s+
| |
| | 40-60
| |
| | varies (?)
| |
| |-
| |
| |Grade
| |
| | typically high grade
| |
| | typically low grade
| |
| | often low
| |
| |-
| |
| |IHC
| |
| | p53+ diffuse, WT-1 +ve, D2-40 +ve, CA-125 +ve
| |
| | WT-1 -ve
| |
| | CK7 +ve, CK20 +ve (others CK7 +ve, CK20 -ve)
| |
| |-
| |
| |Main DDx
| |
| | poorly diff. endometrioid
| |
| | serous |
| |
| | metastatic tumour (usually GI)
| |
| |-
| |
| |}
| |
| | |
| {| class="wikitable sortable" | | {| class="wikitable sortable" |
| !Type | | !Type |