Difference between revisions of "An introduction to gynecologic pathology"

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An introduction to gynecologic pathology (view source)

Revision as of 21:48, 25 August 2012

740 bytes added ,  21:48, 25 August 2012
→‎Introduction to gynecologic tumours: chg table
(→‎Microscopic: fix sp.)
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'''Where to start when considering a malignant (epithelial) tumour of the gynecologic tract:'''
'''Where to start when considering a malignant (epithelial) tumour of the gynecologic tract:'''
{| class="wikitable"
{| class="wikitable"
| || '''Serous''' || '''Endometrioid'''  || '''Mucinous'''  
|
| '''Serous'''
| '''Endometrioid''' 
| '''Mucinous'''  
|-
|-
|Characteristics || cilia, columnar cells<br>[[psammoma bodies]], papillary arch. || gland forming, endometrium-like || mucinous glands, colon-like
|Characteristics
| cilia, columnar cells<br>[[psammoma bodies]], papillary arch.
| gland forming, endometrium-like
| mucinous glands, colon-like
|-
|-
|Differentiators || cilia, psammoma bodies || squamous metaplasia || mucin, lack of [[necrosis]]
|Differentiators
| cilia, psammoma bodies
| squamous metaplasia
| mucin, lack of [[necrosis]]
|-
|-
|Associations || atrophy || endometriosis, endometrial hyperplasia || (?)
|Associations
| atrophy
| endometriosis, endometrial hyperplasia
| (?)
|-
|-
|Typical age || usually 60s+ || 40-60 || varies (?)
|Typical age
| usually 60s+
| 40-60
| varies (?)
|-
|-
|Grade || typically high grade || typically low grade || often low
|Grade
| typically high grade
| typically low grade
| often low
|-
|-
|IHC || p53+ diffuse, WT-1 +ve, D2-40 +ve, CA-125 +ve || WT-1 -ve || CK7 +ve, CK20 +ve (others CK7 +ve, CK20 -ve)
|IHC
| p53+ diffuse, WT-1 +ve, D2-40 +ve, CA-125 +ve
| WT-1 -ve
| CK7 +ve, CK20 +ve (others CK7 +ve, CK20 -ve)
|-
|-
|Main DDx || poorly diff. endometrioid  || serous || metastatic tumour (usually GI)
|Main DDx
| poorly diff. endometrioid 
| serous |
| metastatic tumour (usually GI)
|-
|}
 
{| class="wikitable sortable"
!Type
!Characteristics
!Differentiators
!Associations
!Typical age
!Grade
!IHC
!Main DDx
|-
| '''Serous'''
| cilia, columnar cells<br>[[psammoma bodies]], papillary arch.
| cilia, psammoma bodies
| atrophy
| usually 60s+
| typically high grade
| p53+ diffuse, WT-1 +ve, D2-40 +ve, CA-125 +ve
| poorly diff. endometrioid
|-
| '''Endometrioid'''  
| gland forming, endometrium-like
| squamous metaplasia
| endometriosis, endometrial hyperplasia
| 40-60
| typically low grade
| WT-1 -ve
| serous
|-
| '''Mucinous'''
| mucinous glands, colon-like
| mucin, lack of [[necrosis]]
| (?)
| varies (?)
| often low
| CK7 +ve, CK20 +ve (others CK7 +ve, CK20 -ve) |
| metastatic tumour (usually GI)
|-
|-
|}
|}
Michael
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