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Difference between revisions of "Uterine cervix"
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nl update 3
m (→Adenocarcinoma of the uterine cervix: +image links) |
(nl update 3) |
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*Abbreviated ''MGH''. | *Abbreviated ''MGH''. | ||
===General=== | ===General=== | ||
*Associated with OCP use.<ref name=pmid10757337>{{Cite journal | last1 = Zaino | first1 = RJ. | title = Glandular lesions of the uterine cervix. | journal = Mod Pathol | volume = 13 | issue = 3 | pages = 261-74 | month = Mar | year = 2000 | doi = 10.1038/modpathol.3880047 | PMID = 10757337 | URL = http://www.nature.com/modpathol/journal/v13/n3/full/3880047a.html }}</ref> | *Associated with [[OCP]] use.<ref name=pmid10757337>{{Cite journal | last1 = Zaino | first1 = RJ. | title = Glandular lesions of the uterine cervix. | journal = Mod Pathol | volume = 13 | issue = 3 | pages = 261-74 | month = Mar | year = 2000 | doi = 10.1038/modpathol.3880047 | PMID = 10757337 | URL = http://www.nature.com/modpathol/journal/v13/n3/full/3880047a.html }}</ref> | ||
===Microscopic=== | ===Microscopic=== | ||
Features:<ref name=pmid10757337/> | Features:<ref name=pmid10757337/> | ||
*Cytologically benign - '''important'''. | *Cytologically benign - '''important'''. | ||
** | **Usually cuboidal morphology. | ||
**Typically clear cytoplasm. | **Typically clear cytoplasm. | ||
*Crowded small glands (classic), reticular or solid. | *Crowded small glands (classic), reticular or solid. | ||
Significant negatives: | |||
*Nuclear atypia absent. | |||
*[[NC ratio]] not significantly increased. | |||
DDx: | DDx: | ||
*Adenocarcinoma in situ | *[[Adenocarcinoma of the uterine cervix]], in situ. | ||
*Endometrial mucinous microglandular adenocarcinoma - very rare.<ref name=pmid16306789>{{Cite journal | last1 = Giordano | first1 = G. | last2 = D'Adda | first2 = T. | last3 = Gnetti | first3 = L. | last4 = Merisio | first4 = C. | last5 = Melpignano | first5 = M. | title = Endometrial mucinous microglandular adenocarcinoma: morphologic, immunohistochemical features, and emphasis in the human papillomavirus status. | journal = Int J Gynecol Pathol | volume = 25 | issue = 1 | pages = 77-82 | month = Jan | year = 2006 | doi = | PMID = 16306789 }}</ref> | |||
Images: | |||
*[http://www.nature.com/modpathol/journal/v13/n3/fig_tab/3880047f14.html#figure-title MGH (nature.com)]. | *[http://www.nature.com/modpathol/journal/v13/n3/fig_tab/3880047f14.html#figure-title MGH (nature.com)]. | ||
*[http://sunnybrook.ca/uploads/cx_MGH_5_vd.jpg MGH (sunnybrook.ca)].<ref>URL: [http://sunnybrook.ca/content/?page=Dept_LabS_APath_GynPath_ImgAt_Cvx_neo_micro http://sunnybrook.ca/content/?page=Dept_LabS_APath_GynPath_ImgAt_Cvx_neo_micro]. Accessed on: 25 February 2012.</ref> | *[http://sunnybrook.ca/uploads/cx_MGH_5_vd.jpg MGH (sunnybrook.ca)].<ref>URL: [http://sunnybrook.ca/content/?page=Dept_LabS_APath_GynPath_ImgAt_Cvx_neo_micro http://sunnybrook.ca/content/?page=Dept_LabS_APath_GynPath_ImgAt_Cvx_neo_micro]. Accessed on: 25 February 2012.</ref> | ||
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Features: | Features: | ||
* Nuclei are uniform size and round. | * Nuclei are uniform size and round. | ||
** Nucleoli present. | ** [[Nucleoli]] present. | ||
* +/-Intercellular bridges (due to edema) - common. | * +/-Intercellular bridges (due to edema) - common. | ||
* Uniform cell spacing, i.e. no crowding. | * Uniform cell spacing, i.e. no crowding. | ||
| Line 199: | Line 204: | ||
#**Often cigar-shaped nuclei. | #**Often cigar-shaped nuclei. | ||
#*Coarse chromatin. | #*Coarse chromatin. | ||
#*Small nucleolus or nucleoli. | #*Small nucleolus or [[nucleoli]]. | ||
#+/-Mitoses. | #+/-Mitoses. | ||
#+/-Reduced cytoplasmic mucin. | #+/-Reduced cytoplasmic mucin. | ||
| Line 269: | Line 274: | ||
DDx: | DDx: | ||
*[[Microglandular hyperplasia]] - [[NC ratio]] normal, no nuclear atypia. | |||
*[[Endocervical adenocarcinoma in situ]]. | *[[Endocervical adenocarcinoma in situ]]. | ||
*Metastatic adenocarcinoma. | *Metastatic adenocarcinoma. | ||