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Difference between revisions of "Peripheral nerve sheath tumours"
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Peripheral nerve sheath tumours (view source)
Revision as of 20:26, 12 June 2012
, 20:26, 12 June 2012→Neurofibroma
(→Schwannoma: subsections -- for subtypes) |
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Classification:<ref name=pmid15486243>{{Cite journal | last1 = Wilkinson | first1 = LM. | last2 = Manson | first2 = D. | last3 = Smith | first3 = CR. | title = Best cases from the AFIP: plexiform neurofibroma of the bladder. | journal = Radiographics | volume = 24 Suppl 1 | issue = | pages = S237-42 | month = Oct | year = 2004 | doi = 10.1148/rg.24si035170 | PMID = 15486243 }}</ref> | Classification:<ref name=pmid15486243>{{Cite journal | last1 = Wilkinson | first1 = LM. | last2 = Manson | first2 = D. | last3 = Smith | first3 = CR. | title = Best cases from the AFIP: plexiform neurofibroma of the bladder. | journal = Radiographics | volume = 24 Suppl 1 | issue = | pages = S237-42 | month = Oct | year = 2004 | doi = 10.1148/rg.24si035170 | PMID = 15486243 }}</ref> | ||
#Localized - sporatic. | #Localized - sporatic. | ||
#Diffuse - | #Diffuse - usually poorly defined, young adults and children; sporatic. | ||
#Plexiform - | #Plexiform - associated with NF1. | ||
===Gross/radiologic=== | ===Gross/radiologic=== | ||
| Line 198: | Line 198: | ||
Features: | Features: | ||
*Spindle cells with wavy nuclei without pleomorphism - '''key feature'''. | *Spindle cells with wavy nuclei without pleomorphism - '''key feature'''. | ||
**Often described as "shredded carrots". | |||
*May be arranged in fascicles and intermixed with collagen. | *May be arranged in fascicles and intermixed with collagen. | ||
**Often no pattern is apparent. | **Often no pattern is apparent. | ||
*Moderate increase of cellularity vis-a-vis normal dermis. | *Moderate increase of cellularity vis-a-vis normal dermis. | ||
*May be poorly or well-circumscribed. | *May be poorly or well-circumscribed. | ||
*+/-Plexiform growth pattern - "bag of worms".<ref name=pmid17893219/> | *+/-Plexiform growth pattern - "bag of worms".<ref name=pmid17893219/> | ||
**Multiple well-circumscribed nests. | |||
*Mast cells<ref name=pmid20233971>{{Cite journal | last1 = Staser | first1 = K. | last2 = Yang | first2 = FC. | last3 = Clapp | first3 = DW. | title = Mast cells and the neurofibroma microenvironment. | journal = Blood | volume = 116 | issue = 2 | pages = 157-64 | month = Jul | year = 2010 | doi = 10.1182/blood-2009-09-242875 | PMID = 20233971 }}</ref> - one has to look for them at high power. | *Mast cells<ref name=pmid20233971>{{Cite journal | last1 = Staser | first1 = K. | last2 = Yang | first2 = FC. | last3 = Clapp | first3 = DW. | title = Mast cells and the neurofibroma microenvironment. | journal = Blood | volume = 116 | issue = 2 | pages = 157-64 | month = Jul | year = 2010 | doi = 10.1182/blood-2009-09-242875 | PMID = 20233971 }}</ref> - one has to look for them at high power. | ||
**Very useful for confirming the low power suspicion. | |||
DDx: | DDx: | ||