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Difference between revisions of "Uterine cervix"
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endocervical adenocarcinoma in situ, inv. AIS
(endocervical adenocarcinoma in situ, inv. AIS) |
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# Both perinuclear clearing and nuclear changes are essential. | # Both perinuclear clearing and nuclear changes are essential. | ||
# Benign cells have a small nucleus that is peripheral. | # Benign cells have a small nucleus that is peripheral. | ||
==Endocervical adenocarcinoma in situ== | |||
*[[AKA]] ''adenocarcinoma in situ'', abbreviated ''AIS''. | |||
===General=== | |||
*Usually to [[HPV]]. | |||
*May be found together with squamous neoplasias of the cervix. | |||
*AIS of the cervix is much less common than squamous dysplasia of the cervix/SCC of the cervix. | |||
===Microscopic=== | |||
Features: | |||
*Nuclear changes - '''key feature''': | |||
**Nuclear crowding. | |||
**Nuclear hyperchromasia. | |||
**Cigar-shaped nuclei. | |||
*+/-Mitoses. | |||
*Cytoplasmic hyperchromasia. | |||
DDx: | |||
*[[Endocervical adenocarcinoma]]. | |||
=Cancer= | =Cancer= | ||
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*[[CIN III]]. | *[[CIN III]]. | ||
== | ==Endocervical adenocarcinoma== | ||
*Adenocarcinoma of the cervix | ===General=== | ||
* | *Adenocarcinoma of the cervix is much less common than squamous dysplasia of the cervix/SCC of the cervix. | ||
*Arises from the endocervical glands. | |||
===Invasive adenocarcinoma=== | ===Invasive adenocarcinoma=== | ||
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*AIS changes - similar to [[colon|colonic]] dysplasia. | *AIS changes - similar to [[colon|colonic]] dysplasia. | ||
*AIS may occur together with CIN. | *AIS may occur together with CIN. | ||
** | **Not infrequently they (AIS, CIN) occur together - both are due, indirectly, to HPV infection. | ||
*May be difficult to be certain of invasion. | *May be difficult to be certain of invasion. | ||
===IHC=== | ===IHC=== | ||
Uterus vs. cervix:<ref>LAE. 15 January 2009.</ref> | Uterus vs. cervix:<ref>LAE. 15 January 2009.</ref> | ||
*Cervix (typically): CEA+, p16+. | *Cervix (typically): CEA +ve, p16 +ve. | ||
** | **ER -ve, PR -ve, vimentin -ve. | ||
*Uterus (typically): vimentin+, ER+, PR+. | *Uterus (typically): vimentin +ve, ER +ve, PR +ve. | ||
** | **CEA -ve, p16 -ve. | ||
=Uncommon non-invasive= | =Uncommon non-invasive= | ||