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Difference between revisions of "Drug toxicity"
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This article covers a few of the distinctive histomorphologic pattern and links to other articles that deal with specific organ systems. | This article covers a few of the distinctive histomorphologic pattern and links to other articles that deal with specific organ systems. | ||
=General principles= | |||
A drug/toxin reaction should be considered if there is: | |||
# Ingestion/exposure. | |||
# An appropriate temporal relation. | |||
# An empirical correlation between the drug/toxin and the pattern. | |||
#* Worsening with re-challenge. | |||
#* Improvement with removal of exposure. | |||
#* Pathologic pattern matches with toxin. | |||
#* Drug/toxin detected within individual. | |||
=Site specific= | |||
==Liver drug toxicity== | |||
*[[Drug-induced liver disease]]. | |||
==Stomach== | |||
*[[Reactive gastropathy]]. | |||
==Small bowel== | |||
*[[Small bowel diaphragm disease]]. | |||
=Specific drugs= | |||
==Sodium polystyrene sulfonate== | ==Sodium polystyrene sulfonate== | ||
[[AKA]] ''Kayexalate'' | :[[AKA]] ''Kayexalate'' (trade name). | ||
===General=== | ===General=== | ||
*Used to treat hyperkalemia. | *Used to treat hyperkalemia. | ||
| Line 12: | Line 33: | ||
*Can cause focal [[necrosis]]. | *Can cause focal [[necrosis]]. | ||
Image | ====Image==== | ||
<gallery> | |||
Image:Cecal_adenocarcinoma.jpg | Kayexalate crystals and adenocarcinoma. (WC) | |||
</gallery> | |||
==Proton pump inhibitor== | |||
{{Main|Proton pump inhibitor effect}} | |||
==Nonsteroidal anti-inflammatory drugs== | |||
{{Main|Nonsteroidal anti-inflammatory drugs}} | |||
==Oral contraceptive pill== | |||
{{Main|Oral contraceptive pill}} | |||
==Minocycline== | |||
*[[Minocycline associated thyroid pigmentation]]. | |||
==Spironolactone== | |||
*[[Spironolactone bodies]]. | |||
=See also= | |||
*[[ | *[[Basics]]. | ||
=References= | |||
{{Reflist|1}} | {{Reflist|1}} | ||
[[Category:Stuff]] | [[Category:Stuff]] | ||