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Difference between revisions of "Plasma cell neoplasms"
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===Multiple myeloma=== | ===Multiple myeloma=== | ||
Diagnosis requires the following:<ref name=pmid18971951>{{cite journal |author=Kyle RA, Rajkumar SV |title=Criteria for diagnosis, staging, risk stratification and response assessment of multiple myeloma |journal=Leukemia |volume=23 |issue=1 |pages=3–9 |year=2009 |month=January |pmid=18971951 |pmc=2627786 |doi=10.1038/leu.2008.291 |url=http://www.nature.com/leu/journal/v23/n1/full/leu2008291a.html}}</ref> | |||
*Calcium (in the serum) is elevated. | #Clonal plasma cells. Must >10% if on bone marrow biopsy. | ||
*[[Anemia]]. | #Monoclonal protein, i.e. paraprotein, in serum or urine. | ||
*Renal failure. | #End-organ damage thought to be due to the neoplasm - mnemonic ''CARL'': | ||
*Lytic bone lesions. | #*Calcium (in the serum) is elevated. | ||
#*[[Anemia]]. | |||
#*Renal failure. | |||
#*Lytic bone lesions. | |||
''CRAB'' (calclium, renal failure, anemia, bony lesions) is another mnemonic.<ref name=pmid12780789>{{Cite journal | title = Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group. | journal = Br J Haematol | volume = 121 | issue = 5 | pages = 749-57 | month = Jun | year = 2003 | doi = | PMID = 12780789 }}</ref> | Note: | ||
*''CRAB'' (calclium, renal failure, anemia, bony lesions) is another mnemonic.<ref name=pmid12780789>{{Cite journal | title = Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group. | journal = Br J Haematol | volume = 121 | issue = 5 | pages = 749-57 | month = Jun | year = 2003 | doi = | PMID = 12780789 }}</ref> | |||
==Microscopic== | ==Microscopic== | ||