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Difference between revisions of "Viruses"
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→Oncogenesis
m (→Human papillomavirus: oncogenesis) |
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====Oncogenesis==== | ====Oncogenesis==== | ||
Quick & dirty explanation of pathogenesis:<ref name=pmid12445661>{{Cite journal | last1 = Münger | first1 = K. | last2 = Howley | first2 = PM. | title = Human papillomavirus immortalization and transformation functions. | journal = Virus Res | volume = 89 | issue = 2 | pages = 213-28 | month = Nov | year = 2002 | doi = | PMID = 12445661 }}</ref><ref name=Ref_PCPBoD8_169>{{Ref PCPBoD8|169}}</ref> | Quick & dirty explanation of pathogenesis:<ref name=pmid12445661>{{Cite journal | last1 = Münger | first1 = K. | last2 = Howley | first2 = PM. | title = Human papillomavirus immortalization and transformation functions. | journal = Virus Res | volume = 89 | issue = 2 | pages = 213-28 | month = Nov | year = 2002 | doi = | PMID = 12445661 }}</ref><ref name=Ref_PCPBoD8_169>{{Ref PCPBoD8|169}}</ref> | ||
*Viral gene E6 | *Virus integrates into host genome. | ||
*Viral gene E7 | **This is accompanied by loss of ''viral gene E2'' (which suppresses function of E6 & E7). | ||
*''Viral gene E6'' dysregulates ''p53''. | |||
*''Viral gene E7'' dysregulates ''RB''. | |||
====Vaccine==== | ====Vaccine==== | ||
Recombinant vaccine (Gardasil, Silgard) - covers:<ref name=pmid21942919>{{Cite journal | last1 = McCormack | first1 = PL. | last2 = Joura | first2 = EA. | title = Spotlight on Quadrivalent Human Papillomavirus(Types 6, 11, 16, 18) Recombinant Vaccine(Gardasil®) in the Prevention of PremalignantGenital Lesions, Genital Cancer, and Genital Warts in Women†. | journal = BioDrugs | volume = 25 | issue = 5 | pages = 339-43 | month = Oct | year = 2011 | doi = 10.2165/11205060-000000000-00000 | PMID = 21942919 }}</ref> | Recombinant vaccine (Gardasil, Silgard) - covers:<ref name=pmid21942919>{{Cite journal | last1 = McCormack | first1 = PL. | last2 = Joura | first2 = EA. | title = Spotlight on Quadrivalent Human Papillomavirus(Types 6, 11, 16, 18) Recombinant Vaccine(Gardasil®) in the Prevention of PremalignantGenital Lesions, Genital Cancer, and Genital Warts in Women†. | journal = BioDrugs | volume = 25 | issue = 5 | pages = 339-43 | month = Oct | year = 2011 | doi = 10.2165/11205060-000000000-00000 | PMID = 21942919 }}</ref> | ||