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Difference between revisions of "Lymph node pathology"
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→Rosai-Dorfman disease
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***Thought to be related to ''peripolesis''; the attachment of a cell to another.<ref name=pmid1577151>{{cite journal |author=Lyons DJ, Gautam A, Clark J, ''et al.'' |title=Lymphocyte macrophage interactions: peripolesis of human alveolar macrophages |journal=Eur. Respir. J. |volume=5 |issue=1 |pages=59–66 |year=1992 |month=January |pmid=1577151 |doi= |url=}}</ref> | ***Thought to be related to ''peripolesis''; the attachment of a cell to another.<ref name=pmid1577151>{{cite journal |author=Lyons DJ, Gautam A, Clark J, ''et al.'' |title=Lymphocyte macrophage interactions: peripolesis of human alveolar macrophages |journal=Eur. Respir. J. |volume=5 |issue=1 |pages=59–66 |year=1992 |month=January |pmid=1577151 |doi= |url=}}</ref> | ||
IHC | Images: | ||
*[http://commons.wikimedia.org/wiki/File:Emperipolesis_-_very_high_mag.jpg Emperipolesis in SHML (WC)]. | |||
*[http://commons.wikimedia.org/wiki/File:Rosai-Dorfman_disease_-_very_high_mag.jpg Rosai-Dorfman disease (WC)]. | |||
*[http://commons.wikimedia.org/wiki/File:Rosai-dorfman.jpg Rosai-Dorfman disease - S100 showing emperipolesis (WC)]. | |||
DDx: | |||
*Other histiocytosis: | |||
**Langerhans cell histiocytosis. | |||
**Erdheim-Chester disease. | |||
*Infection, e.g. Rhinoscleroma (nasopharynx), xanthomatous pyelonephritis. | |||
*Xanthomatous change. | |||
===IHC=== | |||
*CD68 +ve. | *CD68 +ve. | ||
*S100 +ve. | *S100 +ve. | ||
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*CD1a -ve. | *CD1a -ve. | ||
**CD1a positive in Langerhans cell histiocytosis. | **CD1a positive in Langerhans cell histiocytosis. | ||
==Langerhans cell histiocytosis== | ==Langerhans cell histiocytosis== | ||