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Difference between revisions of "Lymph node pathology"
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→Castleman disease: +images
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#*Associated with HHV-8 infection (the same virus implicated in ''Kaposi's sarcoma''). | #*Associated with HHV-8 infection (the same virus implicated in ''Kaposi's sarcoma''). | ||
Notes: | |||
*The subclassification of CD is in some flux. Some authors advocate splitting-out ''HHV-8'' and ''multicentric'' as separate subtypes.<ref name=pmid19546611>{{Cite journal | last1 = Cronin | first1 = DM. | last2 = Warnke | first2 = RA. | title = Castleman disease: an update on classification and the spectrum of associated lesions. | journal = Adv Anat Pathol | volume = 16 | issue = 4 | pages = 236-46 | month = Jul | year = 2009 | doi = 10.1097/PAP.0b013e3181a9d4d3 | PMID = 19546611 }}</ref> | |||
===Microscopic=== | ===Microscopic=== | ||
Hyaline-vascular variant - features:<ref>URL: [http://www.ispub.com/journal/the_internet_journal_of_otorhinolaryngology/volume_9_number_2_11/article/a_rare_case_of_castleman_s_disease_presenting_as_cervical_neck_mass.html http://www.ispub.com/journal/the_internet_journal_of_otorhinolaryngology/volume_9_number_2_11/article/a_rare_case_of_castleman_s_disease_presenting_as_cervical_neck_mass.html]. Accessed on: 15 June 2010.</ref><ref name=Ref_ILNP236>{{Ref ILNP|236}}</ref> | Hyaline-vascular variant (HVV) - features:<ref>URL: [http://www.ispub.com/journal/the_internet_journal_of_otorhinolaryngology/volume_9_number_2_11/article/a_rare_case_of_castleman_s_disease_presenting_as_cervical_neck_mass.html http://www.ispub.com/journal/the_internet_journal_of_otorhinolaryngology/volume_9_number_2_11/article/a_rare_case_of_castleman_s_disease_presenting_as_cervical_neck_mass.html]. Accessed on: 15 June 2010.</ref><ref name=Ref_ILNP236>{{Ref ILNP|236}}</ref> | ||
*Pale concentric (expanded) mantle zone lymphocytes - '''key feature'''. | *Pale concentric (expanded) mantle zone lymphocytes - '''key feature'''. | ||
**"Regressed follicles" - germinal center (pale area) is small. | **"Regressed follicles" - germinal center (pale area) is small. | ||
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*Sinuses effaced (lost). | *Sinuses effaced (lost). | ||
*Mitoses absent. | *Mitoses absent. | ||
Images: | |||
*[http://commons.wikimedia.org/wiki/File:Castleman_disease_-_high_mag.jpg CD HVV - "lollipop" sign - high mag. (WC)]. | |||
*[http://commons.wikimedia.org/wiki/File:Castleman_disease_-_intermed_mag.jpg CD HVV - showing expanded mantle zone - intermed. mag. (WC)]. | |||
Plasma cell variant - features:<ref name=Ref_ILNP236>{{Ref ILNP|236}}</ref> | Plasma cell variant - features:<ref name=Ref_ILNP236>{{Ref ILNP|236}}</ref> | ||