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Difference between revisions of "Lynch syndrome"
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'''Lynch syndrome''', also '''hereditary non-polyposis colorectal cancer syndrome''' (abbreviated '''HNPCC'''), is a constellation of clinical findings caused by a mutation in a mismatch repair gene, of which there are several.<ref name=OMIM120435>{{OMIM|120435}}</ref> | '''Lynch syndrome''', also '''hereditary non-polyposis colorectal cancer syndrome''' (abbreviated '''HNPCC'''), is a constellation of clinical findings caused by a mutation in a mismatch repair gene, of which there are several.<ref name=OMIM120435>{{OMIM|120435}}</ref> | ||
As the name suggests, HNPCC is a form of inherited [[colorectal cancer]] that is not characterized by abundant [[intestinal polyps]] (non-polyposis), as in [[adenomatous polyposis coli]]. | As the name suggests, HNPCC is a form of inherited [[colorectal cancer]] that is not characterized by abundant [[intestinal polyps]] (non-polyposis), as in [[adenomatous polyposis coli]]. | ||
The term ''Lynch syndrome'' is preferred as individuals with this syndrome often present with non-colorectal cancers. | |||
==Clinical== | ==Clinical== | ||