Difference between revisions of "Haematopathology"

Haematopathology (view source)

946 bytes removed , 19:35, 17 August 2010

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 ==Burkitt's lymphoma==
+{{main|Burkitt lymphoma}}
 ===General===
 *Abbreviated ''BL''.
-*Extremely high proliferative rate & rate of apoptosis.
+*Subtyped by etiology.
-===Subtypes===
+===Microsopic===
-*Three subtypes recognized:<ref name=pmid12610094>{{cite journal |author=Bellan C, Lazzi S, De Falco G, Nyongo A, Giordano A, Leoncini L |title=Burkitt's lymphoma: new insights into molecular pathogenesis |journal=J. Clin. Pathol. |volume=56 |issue=3 |pages=188–92 |year=2003 |month=March |pmid=12610094 |pmc=1769902 |doi= |url=http://jcp.bmj.com/cgi/pmidlookup?view=long&pmid=12610094}}</ref>
-#Endemic:
-#*Found in Africa.
-#*EBV (Epstein-Barr virus) associated.<ref name=pmid12610094/>
-#Non-endemic:
-#*Typical of the BL seen in the western world; EBV negative.
-#Immunodeficiency associated:
-#*Associated with HIV infection.
-===Pathophysiology===
-*Origin cell: germinal centre B cells (favoured) vs. memory B cells.<ref name=pmid12610094/>
-*Common translocation t(8;14).<ref name=pmid12610094/>
-===Cytologic definition===
-*t(8;14) (q24;q32) translocation + a few variants or c-myc rearrangement.<ref name=pmid12610094/>
-===Histology===
 *"Starry-sky pattern".
 **The ''stars'' in the pattern are: tingible-bodies laden macrophages.