Difference between revisions of "Haematopathology"

Haematopathology (view source)

1,090 bytes removed , 13:59, 16 August 2010

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 ==Follicular lymphoma==
-===General===
+{{main|Small cell lymphomas}}
-*A very common type of lymphoma.
-*Express Bcl-2.<ref name=pmid18359244>{{cite journal |author=Vitolo U, Ferreri AJ, Montoto S |title=Follicular lymphomas |journal=Crit. Rev. Oncol. Hematol. |volume=66 |issue=3 |pages=248–61 |year=2008 |month=June |pmid=18359244 |doi=10.1016/j.critrevonc.2008.01.014 |url=}}</ref>
-===Microscopic===
-Features:
-*Abundant abnormal lymphoid follicles.
-===IHC===
-Features:<ref name=pmid18359244/>
-*CD10 +ve/-ve.
-*CD5 -ve.
-**+ve in mantle cell lymphoma.
-*CD23 -ve/+ve.
-**+ve in CLL.
-*CD43 -ve.
-**+ve in mantle cell lymphoma, marginal zone lymphoma.
-*CD11c -ve -- flow cytometry only.
-===Molecular===
-*t(14;18)(q32;q21)/IGH-BCL2 in 70-95% of cases.<ref name=pmid18359244/>
-**Should not be confused with t(14;18)(q32;q21)/IGH-MALT1 seen in MALT lymphomas.<ref name=pmid16950858>{{cite journal |author=Bacon CM, Du MQ, Dogan A |title=Mucosa-associated lymphoid tissue (MALT) lymphoma: a practical guide for pathologists |journal=J. Clin. Pathol. |volume=60 |issue=4 |pages=361–72 |year=2007 |month=April |pmid=16950858 |pmc=2001121 |doi=10.1136/jcp.2005.031146 |url=}}</ref>
 ==Diffuse large B-cell lymphoma==