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Difference between revisions of "Small cell lymphomas"
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| Follicle | | Follicle | ||
| Small, centrocytes, centroblasts | | Small, centrocytes, centroblasts | ||
| CD10+, | | CD10+, BCL6+<ref name=Ref_Lester95>{{Ref Lester|95}}</ref> | ||
| t(14,18) | | t(14,18) | ||
| Clinical ? | | Clinical ? | ||
| Line 83: | Line 83: | ||
| Follicle | | Follicle | ||
| Large cells | | Large cells | ||
| CD10, | | CD10, BCL6 | ||
| t(8;14) (q24;q32) | | t(8;14) (q24;q32) | ||
| Rapid growth | | Rapid growth | ||
| Line 95: | Line 95: | ||
| Poor prognosis | | Poor prognosis | ||
| Common among lymphomas | | Common among lymphomas | ||
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|- | |- | ||
| Name | | Name | ||
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| Translocations | | Translocations | ||
| Clinical | | Clinical | ||
| Other | | Other --> | ||
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===General=== | ===General=== | ||
*A very common type of lymphoma. | *A very common type of lymphoma. | ||
*Expresses BCL2 | *Expresses BCL2,<ref name=pmid18359244>{{cite journal |author=Vitolo U, Ferreri AJ, Montoto S |title=Follicular lymphomas |journal=Crit. Rev. Oncol. Hematol. |volume=66 |issue=3 |pages=248–61 |year=2008 |month=June |pmid=18359244 |doi=10.1016/j.critrevonc.2008.01.014 |url=}}</ref> like many other small cell lymphomas. | ||
===Microscopic=== | ===Microscopic=== | ||
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===IHC=== | ===IHC=== | ||
Features:<ref name=pmid18359244/> | Features:<ref name=pmid18359244/> | ||
*CD10 +ve | *CD10 +ve. | ||
*BCL6 +ve. | |||
Others: | |||
*CD5 -ve. | *CD5 -ve. | ||
**+ve in mantle cell lymphoma. | **+ve in mantle cell lymphoma. | ||
| Line 152: | Line 156: | ||
===Microscopic=== | ===Microscopic=== | ||
Features: | Features:<ref>DG. 17 August 2010.</ref> | ||
* | *Small monomorphic lymphoid population. | ||
*Abundant mitoses. | |||
*Scatter epithelioid histiocytes (should not be confused with tingible-body macrophages). | |||
*Sclerosed blood vessels. | |||
DDx: | |||
*Other small cell lymphomas, esp. marginal zone lymphoma. | |||
*Burkitt's lymphoma. | |||
===IHC=== | |||
*CD5 +ve. | |||
*CD43 +ve. | |||
*Cyclin D1 +ve. | |||
Others: | |||
*CD23 -ve. | |||
**Positive in CLL. | |||
===Molecular=== | |||
*t(11;14)(q13;q32).<ref>URL: [http://atlasgeneticsoncology.org/Anomalies/t1114ID2021.html http://atlasgeneticsoncology.org/Anomalies/t1114ID2021.html]. Accessed on: 10 August 2010.</ref> | |||
==MALT lymphoma/Marginal zone lymphoma== | ==MALT lymphoma/Marginal zone lymphoma== | ||