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Difference between revisions of "Small cell lymphomas"
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→Follicular lymphoma
m (→Microscopic) |
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===General=== | ===General=== | ||
*A very common type of lymphoma. | *A very common type of lymphoma. | ||
* | *Expresses BCL2.<ref name=pmid18359244>{{cite journal |author=Vitolo U, Ferreri AJ, Montoto S |title=Follicular lymphomas |journal=Crit. Rev. Oncol. Hematol. |volume=66 |issue=3 |pages=248–61 |year=2008 |month=June |pmid=18359244 |doi=10.1016/j.critrevonc.2008.01.014 |url=}}</ref> | ||
===Microscopic=== | ===Microscopic=== | ||
Features: | Features: | ||
*Abundant abnormal lymphoid follicles. | *Abundant abnormal lymphoid follicles - '''key feature''' - including some of the following: | ||
**Non-polarized mantle zone (normal mantle zone is usu. thicker at capsular aspect). | |||
**Non-polarized germinal center (normal germinal center has dark & light area). | |||
**Loss of tingible body macrophages. | |||
**Sinuses effaced (lost). | |||
====Grading==== | |||
*Grade 1-2: <= 22 centroblasts / HPF; where 1 HPF ~= 0.2376 mm^2 (22 mm eye piece @ 40X objective). | |||
*Grade 3A: >22 centroblasts / HPF; where 1 HPF ~= 0.2376 mm^2 (22 mm eye piece @ 40X objective). | |||
*Grade 3B: only centroblasts (within a nodular architecture). | |||
Notes: | |||
*Significant interobserver variability.<ref>DG. 17 August 2010.</ref> | |||
*Grade 1 & Grade 2 lumped together. | |||
*''Only'' centroblasts ''without'' a nodular architecture is ''[[Diffuse large B cell lymphoma]]'' ([[DLBCL]]). | |||
The usual cut points mentioned by people with [[HPFitis]] are:<ref name=Ref_Sternberg4_813>{{Ref Sternberg4|813}}</ref> | |||
*Grade 1: 0-5 centroblasts / HPF. | |||
*Grade 2: 5-15 centroblasts / HPF. | |||
*Grade 3: >15 centroblasts / HPF. | |||
===IHC=== | ===IHC=== | ||
Features:<ref name=pmid18359244/> | Features:<ref name=pmid18359244/> | ||