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Difference between revisions of "Spindle cell lesions"
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→Malignant fibrous histiocytoma
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==Malignant fibrous histiocytoma== | ==Malignant fibrous histiocytoma== | ||
Work-up (MSH): | Work-up (MSH): | ||
*CD34 - GIST, angiosarcoma, solitary fibrous tumour/hemangiopericytoma. | *CD34 - GIST, angiosarcoma, solitary fibrous tumour/hemangiopericytoma, Kaposi sarcoma. | ||
*S100 - neural marker, sensitive for malignant melanoma. | *S100 - neural marker, sensitive for malignant melanoma, Langerhans cells, clear cell sarcoma. | ||
*Desmin - smooth muscle. | *Desmin - smooth muscle. | ||
*MIB1 - proliferation. | *MIB1 - proliferation. | ||
*CD99 - small round cell tumours, | *CD99 - immature T cells (thymus), small round cell tumours, synovial sarcoma, merkel cell carcinoma, osteosarcoma.<ref name=Ref_DCHH108>{{Ref DCHH|108}}</ref> | ||
**Considered "slutty", i.e. non-specific, by Dr. Fletcher; useful if membranous stain pattern = Ewing sarcoma/PNET. | |||
*BCL2 - synovial sarcoma, [[small cell lymphomas]], spindle cell lipoma.<ref name=Ref_DCHH107>{{Ref DCHH|107}}</ref><ref>URL: [http://ajp.amjpathol.org/cgi/content/full/160/3/759 http://ajp.amjpathol.org/cgi/content/full/160/3/759]. Accessed on: 3 August 2010.</ref> | *BCL2 - synovial sarcoma, [[small cell lymphomas]], spindle cell lipoma.<ref name=Ref_DCHH107>{{Ref DCHH|107}}</ref><ref>URL: [http://ajp.amjpathol.org/cgi/content/full/160/3/759 http://ajp.amjpathol.org/cgi/content/full/160/3/759]. Accessed on: 3 August 2010.</ref> | ||
*PGP 9.5. | *PGP 9.5. | ||