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Difference between revisions of "Heart valves"
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→Biscupid aortic valve: more
(→Biscupid aortic valve: more) |
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===General=== | ===General=== | ||
*Aortic valve usually tricuspid. | *Aortic valve usually tricuspid. | ||
*1-2% of general population.<ref name=pmid18514024>{{cite journal |author=Vallely MP, Semsarian C, Bannon PG |title=Management of the ascending aorta in patients with bicuspid aortic valve disease |journal=Heart Lung Circ |volume=17 |issue=5 |pages=357-63 |year=2008 |month=October |pmid=18514024 |doi=10.1016/j.hlc.2008.01.007 |url=}}</ref> | |||
**Male:female ~ 2:1.<ref name=pmid18799444>{{Cite journal | last1 = Tzemos | first1 = N. | last2 = Therrien | first2 = J. | last3 = Yip | first3 = J. | last4 = Thanassoulis | first4 = G. | last5 = Tremblay | first5 = S. | last6 = Jamorski | first6 = MT. | last7 = Webb | first7 = GD. | last8 = Siu | first8 = SC. | title = Outcomes in adults with bicuspid aortic valves. | journal = JAMA | volume = 300 | issue = 11 | pages = 1317-25 | month = Sep | year = 2008 | doi = 10.1001/jama.300.11.1317 | PMID = 18799444 }}</ref> | *Most common congenital heart defect.<ref name=pmid20579534>{{cite journal |author=Siu SC, Silversides CK |title=Bicuspid aortic valve disease |journal=J. Am. Coll. Cardiol. |volume=55 |issue=25 |pages=2789–800 |year=2010 |month=June |pmid=20579534 |doi=10.1016/j.jacc.2009.12.068 |url=}}</ref> | ||
**1-2% of general population.<ref name=pmid18514024>{{cite journal |author=Vallely MP, Semsarian C, Bannon PG |title=Management of the ascending aorta in patients with bicuspid aortic valve disease |journal=Heart Lung Circ |volume=17 |issue=5 |pages=357-63 |year=2008 |month=October |pmid=18514024 |doi=10.1016/j.hlc.2008.01.007 |url=}}</ref> | |||
***Male:female ~ 2:1.<ref name=pmid18799444>{{Cite journal | last1 = Tzemos | first1 = N. | last2 = Therrien | first2 = J. | last3 = Yip | first3 = J. | last4 = Thanassoulis | first4 = G. | last5 = Tremblay | first5 = S. | last6 = Jamorski | first6 = MT. | last7 = Webb | first7 = GD. | last8 = Siu | first8 = SC. | title = Outcomes in adults with bicuspid aortic valves. | journal = JAMA | volume = 300 | issue = 11 | pages = 1317-25 | month = Sep | year = 2008 | doi = 10.1001/jama.300.11.1317 | PMID = 18799444 }}</ref> | |||
*Inherited in autosomal dominant pattern. | *Inherited in autosomal dominant pattern. | ||
**NOTCH1 gene - implicated.<ref name=pmid16025100>{{Cite journal | last1 = Garg | first1 = V. | last2 = Muth | first2 = AN. | last3 = Ransom | first3 = JF. | last4 = Schluterman | first4 = MK. | last5 = Barnes | first5 = R. | last6 = King | first6 = IN. | last7 = Grossfeld | first7 = PD. | last8 = Srivastava | first8 = D. | title = Mutations in NOTCH1 cause aortic valve disease. | journal = Nature | volume = 437 | issue = 7056 | pages = 270-4 | month = Sep | year = 2005 | doi = 10.1038/nature03940 | PMID = 16025100 }}</ref> | **NOTCH1 gene - implicated.<ref name=pmid16025100>{{Cite journal | last1 = Garg | first1 = V. | last2 = Muth | first2 = AN. | last3 = Ransom | first3 = JF. | last4 = Schluterman | first4 = MK. | last5 = Barnes | first5 = R. | last6 = King | first6 = IN. | last7 = Grossfeld | first7 = PD. | last8 = Srivastava | first8 = D. | title = Mutations in NOTCH1 cause aortic valve disease. | journal = Nature | volume = 437 | issue = 7056 | pages = 270-4 | month = Sep | year = 2005 | doi = 10.1038/nature03940 | PMID = 16025100 }}</ref> | ||
===Significance=== | ===Significance=== | ||
| Line 242: | Line 243: | ||
*30% develop serious morbidity.<ref name=pmid18514024/> | *30% develop serious morbidity.<ref name=pmid18514024/> | ||
*Associated with early development of [[calcific aortic stenosis]]. | *Associated with early development of [[calcific aortic stenosis]]. | ||
===Gross=== | |||
Features - either: | |||
#Raphe does not reach the free margin of the cusp. | |||
#No raphe - uncommon.<ref name=pmid9987528>{{Cite journal | last1 = Sabet | first1 = HY. | last2 = Edwards | first2 = WD. | last3 = Tazelaar | first3 = HD. | last4 = Daly | first4 = RC. | title = Congenitally bicuspid aortic valves: a surgical pathology study of 542 cases (1991 through 1996) and a literature review of 2,715 additional cases. | journal = Mayo Clin Proc | volume = 74 | issue = 1 | pages = 14-26 | month = Jan | year = 1999 | doi = 10.4065/74.1.14 | PMID = 9987528 }}</ref> | |||
Note: | |||
*Raphe ~ suture.<ref>URL: [http://dictionary.reference.com/browse/raphe http://dictionary.reference.com/browse/raphe]. Accessed on: 25 February 2012.</ref> | |||
==Tumours== | ==Tumours== | ||