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Difference between revisions of "Heart valves"
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→Heart valve amyloidosis
(→Amyloidosis of heart valves: more) |
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| Line 89: | Line 89: | ||
*Primarily at the base of the valve, i.e. there is relative sparing the free edge. | *Primarily at the base of the valve, i.e. there is relative sparing the free edge. | ||
== | ==Localized dystrophic heart valve amyloidosis== | ||
===General=== | ===General=== | ||
*Common:<ref name=pmid6190729>{{Cite journal | last1 = Cooper | first1 = JH. | title = Localized dystrophic amyloidosis of heart valves. | journal = Hum Pathol | volume = 14 | issue = 7 | pages = 649-53 | month = Jul | year = 1983 | doi = | PMID = 6190729 }}</ref> | *Common:<ref name=pmid6190729>{{Cite journal | last1 = Cooper | first1 = JH. | title = Localized dystrophic amyloidosis of heart valves. | journal = Hum Pathol | volume = 14 | issue = 7 | pages = 649-53 | month = Jul | year = 1983 | doi = | PMID = 6190729 }}</ref> | ||
**~80% of valves with calcific degeneration, i.e. [[calcific aortic stenosis]]. | **~80% of valves with calcific degeneration, i.e. [[calcific aortic stenosis]]. | ||
**~50% of valves with post-rheumatic sclerosis. | **~50% of valves with post-rheumatic sclerosis. | ||
*Not seen in acute disease | *Not seen in acute disease and healed endocarditis.<ref name=pmid6190729/> | ||
===Microscopic=== | ===Microscopic=== | ||
Features: | Features:<ref name=pmid6190729/> | ||
*Pink amorphous material - '''key feature'''. | *Pink amorphous material - '''key feature'''. | ||
** | **Usually around the calcific foci. | ||
DDx: | |||
*Systemic [[amyloidosis]], e.g. [[senile systemic amyloidosis]], AL-amyloidosis. | |||
===Stains=== | ===Stains=== | ||