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Difference between revisions of "Gastrointestinal tract polyps"
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Gastrointestinal tract polyps (view source)
Revision as of 17:14, 12 July 2010
, 17:14, 12 July 2010→Traditional adenoma: clarification
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===Traditional adenoma=== | ===Traditional adenoma=== | ||
====Microscopic==== | ====Microscopic==== | ||
*Nuclear changes - '''key feature'''. | *Nuclear changes at the surface (of the mucosa) - '''key feature'''. | ||
**Loss of nuclear polarity (nuclei no longer on basement membrane). | **Loss of nuclear polarity (nuclei no longer on basement membrane). | ||
**Nuclear crowding/pseudostratification (key feature). | **Nuclear crowding/pseudostratification (key feature). | ||
** | **Hyperchromasia (more blue). | ||
**Cigar-shaped (elongated) nucleus - length:width > 3:1 (key feature). | **Cigar-shaped (elongated) nucleus - length:width > 3:1 (key feature). | ||
***Normal nuclei are round. | ***Normal nuclei are round. | ||
*Loss/decrease of goblet cells. | *Loss/decrease of goblet cells. | ||
*Cytoplasmic hyperchromasia. | *Cytoplasmic hyperchromasia. | ||
Notes: | |||
*Nuclear changes deep to the surface are non-neoplastic if normal appearing mucosa (with small round nuclei) is superficial to it; mucosa that is more blue and atypical deep ''and'' less blue without nuclear atypia at the surface is said to be "maturing". | |||
**Classically, adenomatous polyps have "reverse maturation": | |||
***The surface is more hyperchromatic (more blue). | |||
***The base is more mature (more globlet cells, no nuclear changes -- less blue). | |||
====Typing==== | ====Typing==== | ||