48,830
edits
Difference between revisions of "Neuropathology"
Jump to navigation
Jump to search
m
→Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)
| Line 372: | Line 372: | ||
===Diagnosis=== | ===Diagnosis=== | ||
*Proven '' | *Proven ''Notch 3'' mutation. | ||
*Can be diagnosed on a skin biopsy. | |||
*IHC for ''Notch 3'' -- +ve staining in Notch 3 mutants. | |||
===Histology=== | ===Histology=== | ||
*Electron microscopy | Features: | ||
*Subcortical infarcts. | |||
Note: | |||
*No cortical involvement. | |||
DDx: | |||
*Amyloidosis. | |||
*Binswanger's disease - multi-infarct dementia affecting subcortical white mater. | |||
**Often diagnosed as ''Alzheimer's disease'' in the past. | |||
===Electron microscopy=== | |||
*Granular osmiophilic material (GOM). | |||
==See also== | ==See also== | ||