Smoking-related interstitial fibrosis

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Smoking-related interstitial fibrosis
Diagnosis in short

LM septal thickening of alveoli with thick collagen bundles (described as "ropy") and hyperplastic smooth muscle fibres; minimal inflammation
LM DDx usual interstitial pneumonia
Gross subpleural and centrilobular predominance
Site lung

Associated Dx emphysema, respiratory bronchiolitis
Clinical history smoking
Prognosis benign, better than UIP

Smoking-related interstitial fibrosis, abbreviated SRIF, is a benign pauci-inflammatory scarring associated with smoking.


  • Associated with emphysema and respiratory bronchiolitis.[1]



  • Subpleural and centrilobular predominance.[1]



  • Septal thickening of alveoli with:
    • Thick collagen bundles - may be described as "ropy".[3]
    • Hyperplastic smooth muscle fibres.
  • Minimal inflammation.



See also


  1. 1.0 1.1 1.2 1.3 Katzenstein, AL. (Jan 2012). "Smoking-related interstitial fibrosis (SRIF), pathogenesis and treatment of usual interstitial pneumonia (UIP), and transbronchial biopsy in UIP.". Mod Pathol 25 Suppl 1: S68-78. doi:10.1038/modpathol.2011.154. PMID 22214972.
  2. 2.0 2.1 Chae, KJ.; Jin, GY.; Jung, HN.; Kwon, KS.; Choi, H.; Lee, YC.; Chung, MJ.; Park, HS. (2016). "Differentiating Smoking-Related Interstitial Fibrosis (SRIF) from Usual Interstitial Pneumonia (UIP) with Emphysema Using CT Features Based on Pathologically Proven Cases.". PLoS One 11 (9): e0162231. doi:10.1371/journal.pone.0162231. PMID 27611866.
  3. 3.0 3.1 Primiani, A.; Dias-Santagata, D.; Iafrate, AJ.; Kradin, RL. (2014). "Pulmonary adenocarcinoma mutation profile in smokers with smoking-related interstitial fibrosis.". Int J Chron Obstruct Pulmon Dis 9: 525-31. doi:10.2147/COPD.S61932. PMID 24920890.