Sickle cell disease

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Extravascular drepanocytes (sickled red blood cells) in renal medullary carcinoma. H&E stain.

Sickle cell disease, also sickle cell anemia, is a heritable haematologic disorder associated with serious pathologies.

Red blood cells

  • Sickled red blood cells (drepanocytes).




  • It may lead to auto infarction - result in hypofunction.
    • Splenectomy have increased risk from polysaccharide encapsulated bacteria, i.e. Neisseria meningitis, Haemophilus influenzae, and Streptococcus pneumoniae.


  • Pigment stones.


Femoral head

See also


  1. Hurtova, M.; Bachir, D.; Lee, K.; Calderaro, J.; Decaens, T.; Kluger, MD.; Zafrani, ES.; Cherqui, D. et al. (Apr 2011). "Transplantation for liver failure in patients with sickle cell disease: challenging but feasible.". Liver Transpl 17 (4): 381-92. doi:10.1002/lt.22257. PMID 21445921.
  2. 2.0 2.1 2.2 2.3 2.4 Davis CJ, Mostofi FK, Sesterhenn IA (January 1995). "Renal medullary carcinoma. The seventh sickle cell nephropathy". Am. J. Surg. Pathol. 19 (1): 1–11. PMID 7528470.