Post-infectious glomerulonephritis

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Post-infectious glomerulonephritis
Diagnosis in short

Post-infectious glomerulonephritis. H&E stain.

LM +/-neutrophils in glomerulus, glomerular crescents
EM subepithelial deposits, hump-like
IF granular immune deposits
Site kidney - see medical kidney diseases

Associated Dx post-infection, e.g. pneumonia
Signs nephritic syndrome (proteinuria, hypertension, azotemia, RBC casts, oliguria, hematuria)
Prevalence uncommon
Prognosis usually good

Post-infectious glomerulonephritis, abbreviated PIGN, is a rarely biopsied glomerulonephritis classically associated with a streptococcal infection.

General

  • Classically post-streptococcal infection.[1][2]
    • Lab test: Antistreptolysin O titer (ASOT) +ve.

Clinical:

Microscopic

Features:

Images

www:

IF

  • Granular immune deposits.

EM

  • Subepithelial deposits - hump-like.[3]
    • Larger when measured perpendicular to the basement membrane, if compared to membranous nephropathy.
    • Typically focal.

See also

References

  1. Barbiano Di Belgiojoso, G.; Genderini, A.; Ferrario, F.. "[Post-infectious glomerulonephritis].". G Ital Nefrol 20 (2): 184-99. PMID 12746805.
  2. 2.0 2.1 Stratta, P.; Musetti, C.; Barreca, A.; Mazzucco, G. (Jun 2014). "New trends of an old disease: the acute post infectious glomerulonephritis at the beginning of the new millenium.". J Nephrol 27 (3): 229-39. doi:10.1007/s40620-013-0018-z. PMID 24777751.
  3. Sung, HY.; Lim, CH.; Shin, MJ.; Kim, BS.; Kim, YO.; Song, HC.; Kim, SY.; Choi, EJ. et al. (Dec 2007). "A case of post-streptococcal glomerulonephritis with diffuse alveolar hemorrhage.". J Korean Med Sci 22 (6): 1074-8. PMID 18162726.