Medial calcific sclerosis
(Redirected from Monckeberg's arteriosclerosis)
Medial calcific sclerosis is a type of arteriosclerosis that has no significant clinical impact.
| Medial calcific sclerosis | |
|---|---|
| Diagnosis in short | |
 Medial calcific sclerosis. H&E stain. | |
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| Synonyms | Moenckeberg medial calcific sclerosis, calcific medial sclerosis of Monckeberg, Mönckeberg's arteriosclerosis (also written Monckeberg's arteriosclerosis) |
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| LM | calcifications of the tunica media |
| LM DDx | atherosclerosis |
| Site | blood vessels - arteries |
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| Prognosis | good |
| Treatment | (nothing) |
It is also known as Moenckeberg medial calcific sclerosis, calcific medial sclerosis of Monckeberg, and Mönckeberg's arteriosclerosis (also written Monckeberg's arteriosclerosis).
General
- Usually of no clinical consequence.
- May impact vascular assessments using ultrasound.[1]
Microscopic
Features:[2]
- Medial calcification (purple irregular stuff on H&E -- calcium phosphate).
Note:
- Lumen unaffected.
- It has been suggested that it usually involves the internal elastic lamina.[3]
DDx:[4]
- Atherosclerosis (severe) - intimal hyperplasia with stenosis, calcifications typically in tunica intima.
Images
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MCS - low mag. (WC) -
MCS - intermed. mag. (WC) -
MCS - high mag. (WC) -
MCS - intermed. mag. (WC) -
MCS - high mag. (WC)
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MCS. (WC)
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RIGHT LEG, BELOW KNEE AMPUTATION: - MINIMAL-TO-MILD LARGE VESSEL ATHEROSCLEROSIS, SEE COMMENT. - MEDIAL CALCIFIC SCLEROSIS. - SKIN WITH DERMAL FIBROSIS. COMMENT: The sections may not be representative of disease in the distal vascular bed.
See also
References
- ↑ Suludere MA, Danesh SK, Killeen AL, Crisologo PA, Malone M, Siah MC, Lavery LA (July 2023). "Mönckeberg's Medial Calcific Sclerosis Makes Traditional Arterial Doppler's Unreliable in High-Risk Patients with Diabetes". Int J Low Extrem Wounds: 15347346231191588. doi:10.1177/15347346231191588. PMID 37525549.
- ↑ Klatt, Edward C. (2006). Robbins and Cotran Atlas of Pathology (1st ed.). Saunders. pp. 7. ISBN 978-1416002741.
- ↑ Micheletti RG, Fishbein GA, Currier JS, Fishbein MC (January 2008). "Mönckeberg sclerosis revisited: a clarification of the histologic definition of Mönckeberg sclerosis". Arch Pathol Lab Med 132 (1): 43–7. doi:10.5858/2008-132-43-MSRACO. PMID 18181672.
- ↑ Dos Santos VP, Pozzan G, Castelli V, Caffaro RA (2021). "Arteriosclerosis, atherosclerosis, arteriolosclerosis, and Monckeberg medial calcific sclerosis: what is the difference?". J Vasc Bras 20: e20200211. doi:10.1590/1677-5449.200211. PMC 8276643. PMID 34290756. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276643/.