Medial calcific sclerosis

Medial calcific sclerosis
Diagnosis in short
Medial calcific sclerosis. H&E stain.
Synonyms	Moenckeberg medial calcific sclerosis, calcific medial sclerosis of Monckeberg, Mönckeberg's arteriosclerosis (also written Monckeberg's arteriosclerosis)
LM	calcifications of the tunica media
LM DDx	atherosclerosis
Site	blood vessels - arteries
Prognosis	good
Treatment	(nothing)

Medial calcific sclerosis is a type of arteriosclerosis that has no significant clinical impact.

It is also known as Moenckeberg medial calcific sclerosis, calcific medial sclerosis of Monckeberg, and Mönckeberg's arteriosclerosis (also written Monckeberg's arteriosclerosis).

General

• Usually of no clinical consequence.

Microscopic

Features:

• Medial calcification (purple irregular stuff on H&E -- calcium phosphate).

Note:

• Lumen unaffected.

DDx:

• Atherosclerosis (severe) - intimal hyperplasia with stenosis, calcifications typically in tunica intima.

Images

• 

  MCS - low mag. (WC)

• 

  MCS - intermed. mag. (WC)

• 

  MCS - high mag. (WC)

• 

  MCS - intermed. mag. (WC)

• 

  MCS - high mag. (WC)

• 

  MCS. (WC)

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RIGHT LEG, BELOW KNEE AMPUTATION:
- MINIMAL-TO-MILD LARGE VESSEL ATHEROSCLEROSIS, SEE COMMENT.
- MEDIAL CALCIFIC SCLEROSIS.
- SKIN WITH DERMAL FIBROSIS.

COMMENT:
The sections may not be representative of disease in the distal vascular bed.

See also

• Vascular disease.