Columnar cell change of the breast
From Libre Pathology
Columnar cell change of the breast, usually columnar cell change (abbreviated CCC), is a benign finding in breast pathology.
It is also known as blunt duct adenosis.
- Secretory cells (line gland lumen) have columnar morphology.
- May have "apical snouts".
- Blebs or round balls eosinophilic material appear to be adjacent to the cell at their luminal surface.
- The snouts are attached to the cell-- appear as round ball only in the plane of section.
- Cytoplasm +/-eosinophilia.
- Often (purple) luminal calcifications.
- Flat epithelial atypia (>2 cell layers).
- If the columnar cells shows low to intermediate grade atypia the process is termed "flat epithelial atypia"
- If higher grade atypia is present the lesion is termed "flat DCIS" (clinging carcinoma).
- Usually not reported.