Chagas disease
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Chagas disease, also known as American trypanosomiasis, is an infectious disease that affect various organs.
General
- Essentially a South American disease.
- Etiology: protozoa Trypanosoma cruzi - transmitted by reduvid bugs,[1] also known as kissing bug.[2]
Clinical:[3]
- Depends on phase of infection.
- Arrhythmias (late).
- Toxic megacolon.[4]
- Chagas disease esophagopathy.[5]
- Achalasia-like pathology with dilation of the esophagus.
Dx:[6]
- Usually serology.
- Thin blood smear.
Tx:
- Antimicrobials: benznidazole, nifurtimox.[1]
Microscopic
Features - heart:
- Inflammation - main finding.[3]
- Intramuscular organisms (without an inflammatory response).
- Neuronal loss in atrial ganglia.[7]
DDx:
- Toxoplasmosis.[8] (???)
Images:
IHC
- Anti–T cruzi immunoperoxidase.[7]
See also
References
- ↑ 1.0 1.1 URL: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002348/. Accessed on: 4 December 2011.
- ↑ URL: http://www.who.int/topics/chagas_disease/en/. Accessed on: 1 December 2011.
- ↑ 3.0 3.1 Teixeira, AR.; Nascimento, RJ.; Sturm, NR. (Aug 2006). "Evolution and pathology in chagas disease--a review.". Mem Inst Oswaldo Cruz 101 (5): 463-91. PMID 17072450.
- ↑ Kobayasi, S.; Mendes, EF.; Rodrigues, MA.; Franco, MF. (Nov 1992). "Toxic dilatation of the colon in Chagas' disease.". Br J Surg 79 (11): 1202-3. PMID 1467905.
- ↑ Vicentine, FP.; Herbella, FA.; Allaix, ME.; Silva, LC.; Patti, MG. (Feb 2014). "Comparison of idiopathic achalasia and Chagas' disease esophagopathy at the light of high-resolution manometry.". Dis Esophagus 27 (2): 128-33. doi:10.1111/dote.12098. PMID 23795824.
- ↑ URL: http://www.cdc.gov/parasites/chagas/diagnosis.html. Accessed on: 4 December 2011.
- ↑ 7.0 7.1 Marin-Neto, JA.; Cunha-Neto, E.; Maciel, BC.; Simões, MV. (Mar 2007). "Pathogenesis of chronic Chagas heart disease.". Circulation 115 (9): 1109-23. doi:10.1161/CIRCULATIONAHA.106.624296. PMID 17339569.
- ↑ URL: http://path.upmc.edu/cases/case160/micro.html. Accessed on: 8 January 2012.
- ↑ Higuchi, Mde L.; Benvenuti, LA.; Martins Reis, M.; Metzger, M. (Oct 2003). "Pathophysiology of the heart in Chagas' disease: current status and new developments.". Cardiovasc Res 60 (1): 96-107. PMID 14522411.