Cytomegalovirus colitis

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Cytomegalovirus colitis
Diagnosis in short

CMV colitis. H&E stain. (WC)

LM enlarged nucleus - classically in endothelial cells, +/-cytoplasmic inclusions
LM DDx infectious colitis
IHC CMV +ve
Site colon

Associated Dx +/-HIV infection
Clinical history +/-immunosuppression, +/-immune incompetent (e.g. transplant recipients)
Prevalence rare

Cytomegalovirus colitis is a type of colitis caused by cytomegalovirus.

General

  • Uncommon.
  • Immunosuppressed population at risk, e.g. transplant recipients, individuals with HIV.
  • Typically self-limited in immunocompetent patients.[1]

Microscopic

Features:

  • Enlarged nucleus - typically in endothelial cells.
    • Nucleus classically has peripheral clearing - described as "owl's eye".
    • Epithelial cells and lamina propria cells may also be affected.[2]

DDx:

Images

www:

IHC

Others:

  • HSV-1.
  • HSV-2.
  • VZV.
  • EBV.

Images

See also

References

  1. Kim, SH.; Kim, YS.; Kim, HW.; Yoon, HE.; Kim, HK.; Kim, YO.; Yoon, SA. (Apr 2011). "A case of cytomegalovirus colitis in an immunocompetent hemodialysis patient.". Hemodial Int 15 (2): 297-300. doi:10.1111/j.1542-4758.2010.00520.x. PMID 21226839.
  2. URL: http://www.annalsgastro.gr/index.php/annalsgastro/article/view/579. Accessed on: 8 February 2016.
  3. Beaugerie, L.; Cywiner-Golenzer, C.; Monfort, L.; Girard, PM.; Carbonnel, F.; Ngô, Y.; Cosnes, J.; Rozenbaum, W. et al. (Apr 1997). "Definition and diagnosis of cytomegalovirus colitis in patients infected by human immunodeficiency virus.". J Acquir Immune Defic Syndr Hum Retrovirol 14 (5): 423-9. PMID 9170416.
  4. Harano, Y.; Kotajima, L.; Arioka, H. (2015). "Case of cytomegalovirus colitis in an immunocompetent patient: a rare cause of abdominal pain and diarrhea in the elderly.". Int J Gen Med 8: 97-100. doi:10.2147/IJGM.S63771. PMID 25767404.