Mammary myofibroblastoma

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Mammary myofibroblastoma
Diagnosis in short

Mammary myofibroblastoma. H&E stain.

Synonyms myofibroblastoma of the breast, breast myofibroblastoma

LM well-circumscribed lesion, wpindle cells without nuclear atypia arranged in fascicles, interspersed thick bundles of collagen.
LM DDx metaplastic breast carcinoma, fibromatosis, leiomyoma of the breast, nodular fasciitis, phyllodes tumour, spindle cell lipoma
IHC CD34 +ve, SMA +ve, desmin, +ve, vimentin +ve, S-100 -ve, beta-catenin -ve
Site breast

Clinical history postmenopausal female or older male
Prevalence rare
Prognosis benign
Treatment excision

Mammary myofibroblastoma, also myofibroblastoma of the breast, is a rare benign pathology of the breast.


  • Rare.
  • Excision = cure.
  • Postmenopausal females and older males.[1][2]


  • In extra-mammary sites the tumour is known as a mammary-type myofibroblastoma may immunohistochemically and histomorphologically overlap with spindle cell lipoma.[3]



  • Well-circumscribed lesion.
  • Spindle cells without nuclear atypia arranged in fascicles.
  • Interspersed thick bundles of collagen.


  • No calcifications.
  • No necrosis.
  • No hemorrhage.






  • CD34 +ve.[3]
  • Desmin +ve.[3]
  • Actin +ve.
  • Vimentin +ve.
  • SMA +ve.[6]


See also


  1. Qureshi, A.; Kayani, N.. "Myofibroblastoma of breast.". Indian J Pathol Microbiol 51 (3): 395-6. PMID 18723968.
  2. 2.0 2.1 Mele, M.; Jensen, V.; Wronecki, A.; Lelkaitis, G. (2011). "Myofibroblastoma of the breast: Case report and literature review.". Int J Surg Case Rep 2 (6): 93-6. doi:10.1016/j.ijscr.2011.02.006. PMC 3199680. PMID 22096693. //
  3. 3.0 3.1 3.2 McMenamin, ME.; Fletcher, CD. (Aug 2001). "Mammary-type myofibroblastoma of soft tissue: a tumor closely related to spindle cell lipoma.". Am J Surg Pathol 25 (8): 1022-9. PMID 11474286.
  4. O'Malley, Frances P.; Pinder, Sarah E. (2006). Breast Pathology: A Volume in Foundations in Diagnostic Pathology series (1st ed.). Churchill Livingstone. pp. 131. ISBN 978-0443066801.
  5. 5.0 5.1 5.2 5.3 Shivali, B.; S, K.; Chandramouleeswari, K.; Anita, S. (Oct 2013). "Myofibroblastoma breast with unusual morphological features. Cytohistopathogical diagnostic pitfalls and role of immunohistochemistry-review of literature.". J Clin Diagn Res 7 (10): 2323-5. doi:10.7860/JCDR/2013/5281.3515. PMID 24298520.
  6. 6.0 6.1 Mnif, H.; Charfi, S.; Abid, N.; Sallemi-Boudawara, T. (Aug 2013). "Mammary myofibroblastoma with leiomyomatous differentiation: case report and literature review.". Pathologica 105 (4): 142-5. PMID 24466766.