Adenoid cystic/basal cell carcinoma of the prostate

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Adenoid cystic/basal cell carcinoma of the prostate
Diagnosis in short

Adenoid cystic/basal cell carcinoma of the prostate. H&E stain.
LM DDx adenoid cystic-like basal cell hyperplasia
IHC BCLA2 +ve, Ki-67 >20, HER2 +ve
Grossing notes prostate biopsy, prostate chips, radical prostatectomy
Staging prostate cancer staging
Site prostate gland

Prevalence very rare
Prognosis usually good

Adenoid cystic/basal cell carcinoma of the prostate, abbreviated ACBCC, is a rare from of prostate cancer that resembles adenoid cystic carcinoma and basal cell carcinoma.

It is also known as adenoid cystic carcinoma of the prostate.[1]

General

  • Rare.
  • Typically indolent - may be aggressive.[2]

Microscopic

Features:

DDx:

Images

IHC

  • HER2/neu +ve (strong).[4]
  • CK34betaE12 +ve (AdCC component).[1]
  • BCL2 +ve.[3]
  • Ki-67 >20%.[3]

See also

References

  1. 1.0 1.1 1.2 McKenney, JK.; Amin, MB.; Srigley, JR.; Jimenez, RE.; Ro, JY.; Grignon, DJ.; Young, RH. (Oct 2004). "Basal cell proliferations of the prostate other than usual basal cell hyperplasia: a clinicopathologic study of 23 cases, including four carcinomas, with a proposed classification.". Am J Surg Pathol 28 (10): 1289-98. PMID 15371944.
  2. Iczkowski, KA.; Ferguson, KL.; Grier, DD.; Hossain, D.; Banerjee, SS.; McNeal, JE.; Bostwick, DG. (Dec 2003). "Adenoid cystic/basal cell carcinoma of the prostate: clinicopathologic findings in 19 cases.". Am J Surg Pathol 27 (12): 1523-9. PMID 14657711.
  3. 3.0 3.1 3.2 Yang, XJ.; McEntee, M.; Epstein, JI. (Dec 1998). "Distinction of basaloid carcinoma of the prostate from benign basal cell lesions by using immunohistochemistry for bcl-2 and Ki-67.". Hum Pathol 29 (12): 1447-50. PMID 9865831.
  4. Iczkowski, KA.; Montironi, R. (Dec 2006). "Adenoid cystic/basal cell carcinoma of the prostate strongly expresses HER-2/neu.". J Clin Pathol 59 (12): 1327-30. doi:10.1136/jcp.2005.035147. PMID 17142577.