Xanthogranulomatous cystitis

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Xanthogranulomatous cystitis is an uncommon chronic form of cystitis that may mimic malignancy.

General

Clinical features - generally nonspecific:[3]

  • Dysuria (pain on urination).
  • +/-Hematuria.
  • Often history of renal stones or recurrent UTIs.

Gross

Microscopic

Features:

  • Foamy macrophages.
  • Chronic inflammatory cells - typically lymphocytes and plasma cells.
  • +/-Cholesterol clefts.

DDx:

IHC

Features:[1]

  • CD68 +ve.
  • Vimentin +ve.

See also

References

  1. 1.0 1.1 Wang, Y.; Han, XC.; Zheng, LQ.; Miao, WL. (2014). "Xanthogranulomatous cystitis imitating bladder neoplasm: a case report and review of literature.". Int J Clin Exp Pathol 7 (11): 8255-8. PMID 25550882.
  2. 2.0 2.1 Ali, AM.; Nelvigi, GG.; Keshavaiah, VG.; Ratkal, CS. (Oct 2014). "Extensive xanthogranulomatous cystitis mimicking bladder cancer.". Urol Ann 6 (4): 373-5. doi:10.4103/0974-7796.141018. PMID 25371622.
  3. Grivas, N. (Oct 2014). "Challenges in the diagnosis of xanthogranulomatous cystitis.". Urol Ann 6 (4): 375-6. doi:10.4103/0974-7796.141019. PMID 25371623.