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Difference between revisions of "Uterine cervix"
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→Uncommon types of cervical cancer: +MDA
(→Uncommon types of cervical cancer: +mesonephric adenocarcinoma) |
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| Line 470: | Line 470: | ||
*PR -ve. | *PR -ve. | ||
*CEA -ve. | *CEA -ve. | ||
==Minimal deviation adenocarcinoma of the uterine cervix== | |||
*[[AKA]] ''adenoma malignum''. | |||
*[[AKA]] ''minimal deviation adenocarcinoma'', abbreviated ''MDA''. | |||
===General=== | |||
*Rare and difficult diagnosis.<ref name=pmid12828609>{{Cite journal | last1 = Tsuda | first1 = H. | last2 = Mikami | first2 = Y. | last3 = Kaku | first3 = T. | last4 = Akiyama | first4 = F. | last5 = Hasegawa | first5 = T. | last6 = Okada | first6 = S. | last7 = Hayashi | first7 = I. | last8 = Kasamatsu | first8 = T. | title = Interobserver variation in the diagnosis of adenoma malignum (minimal deviation adenocarcinoma) of the uterine cervix. | journal = Pathol Int | volume = 53 | issue = 7 | pages = 440-9 | month = Jul | year = 2003 | doi = | PMID = 12828609 }}</ref> | |||
**Requires a deep sampling;<ref name=pmid22385609>{{Cite journal | last1 = Lim | first1 = KT. | last2 = Lee | first2 = IH. | last3 = Kim | first3 = TJ. | last4 = Kwon | first4 = YS. | last5 = Jeong | first5 = JG. | last6 = Shin | first6 = SJ. | title = Adenoma malignum of the uterine cervix: Clinicopathologic analysis of 18 cases. | journal = Kaohsiung J Med Sci | volume = 28 | issue = 3 | pages = 161-4 | month = Mar | year = 2012 | doi = 10.1016/j.kjms.2011.10.009 | PMID = 22385609 }}</ref> thus, usually diagnosed on cone biopsy or hysterectomy. | |||
*Associated with [[Peutz-Jeghers syndrome]].<ref name=pmid21503748>{{Cite journal | last1 = Riegert-Johnson | first1 = D. | last2 = Roberts | first2 = M. | last3 = Gleeson | first3 = FC. | last4 = Krishna | first4 = M. | last5 = Boardman | first5 = L. | title = Case studies in the diagnosis and management of Peutz-Jeghers syndrome. | journal = Fam Cancer | volume = 10 | issue = 3 | pages = 463-8 | month = Sep | year = 2011 | doi = 10.1007/s10689-011-9438-x | PMID = 21503748 }}</ref><ref name=pmid22878090>{{Cite journal | last1 = Ito | first1 = M. | last2 = Minamiguchi | first2 = S. | last3 = Mikami | first3 = Y. | last4 = Ueda | first4 = Y. | last5 = Sekiyama | first5 = K. | last6 = Yamamoto | first6 = T. | last7 = Takakura | first7 = K. | title = Peutz-Jeghers syndrome-associated atypical mucinous proliferation of the uterine cervix: A case of minimal deviation adenocarcinoma ('adenoma malignum') in situ. | journal = Pathol Res Pract | volume = | issue = | pages = | month = Aug | year = 2012 | doi = 10.1016/j.prp.2012.06.008 | PMID = 22878090 }}</ref> | |||
===Microscopic=== | |||
Features:<ref name=Ref_WMSP441-2>{{Ref WMSP|441-2}}</ref> | |||
*Deep infiltrating glands - '''key feature'''. | |||
**Desmoplastic stroma - may be subtle. | |||
**Perivascular and/or perineural location. | |||
*Minimal nuclear atypia. | |||
*Loss of lobular (gland) architecture. † | |||
† '''Not''' a criterion required by all pathologists.<ref name=pmid12828609/> | |||
=See also= | =See also= | ||