Difference between revisions of "Thromboangiitis obliterans"
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'''Thromboangiitis obliterans''', abbreviated '''TAO''', is a rare [[vascular disease]] characterized by recurrent thrombosis. It primarily afflicts young smokers and is also known as '''Buerger disease'''. | '''Thromboangiitis obliterans''', abbreviated '''TAO''', is a rare [[vascular disease]] characterized by recurrent thrombosis. It primarily afflicts young smokers and is also known as '''Buerger disease'''. | ||
It should '''not''' be confused with '''Berger disease''' ([[IgA nephropathy]]). | |||
==General== | ==General== | ||
| Line 12: | Line 12: | ||
Treatment: | Treatment: | ||
*Stop smoking.<ref name=pmid22284771>{{Cite journal | last1 = Dargon | first1 = PT. | last2 = Landry | first2 = GJ. | title = Buerger's disease. | journal = Ann Vasc Surg | volume = 26 | issue = 6 | pages = 871-80 | month = Aug | year = 2012 | doi = 10.1016/j.avsg.2011.11.005 | PMID = 22284771 }}</ref> | *Stop smoking.<ref name=pmid22284771>{{Cite journal | last1 = Dargon | first1 = PT. | last2 = Landry | first2 = GJ. | title = Buerger's disease. | journal = Ann Vasc Surg | volume = 26 | issue = 6 | pages = 871-80 | month = Aug | year = 2012 | doi = 10.1016/j.avsg.2011.11.005 | PMID = 22284771 }}</ref> | ||
===Formal clinical criteria=== | |||
====Simple==== | |||
All of the following - as per ''Shionoya'':<ref name=pmid16722538>{{Cite journal | last1 = Arkkila | first1 = PE. | title = Thromboangiitis obliterans (Buerger's disease). | journal = Orphanet J Rare Dis | volume = 1 | issue = | pages = 14 | month = | year = 2006 | doi = 10.1186/1750-1172-1-14 | PMID = 16722538 | URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1523324/ | PMC = 1523324 }}</ref> | |||
*Smoking. | |||
**No other atherosclerosis risk factors. | |||
*Onset < 50 years old. | |||
*Infrapopliteal arterial occlusions. | |||
*Arm involvement ''or'' phlebitis migrans; | |||
====Complicated==== | |||
All of the following - as per ''Olin'':<ref name=pmid10995867>{{Cite journal | last1 = Olin | first1 = JW. | title = Thromboangiitis obliterans (Buerger's disease). | journal = N Engl J Med | volume = 343 | issue = 12 | pages = 864-9 | month = Sep | year = 2000 | doi = 10.1056/NEJM200009213431207 | PMID = 10995867 | URL = http://www.nejm.org/doi/full/10.1056/NEJM200009213431207 }}</ref> | |||
*Less than 45 years old. | |||
*Current or recent tobacco use. | |||
*Sign or symptoms of distal extremity ischemia (claudication, pain at rest, ulcers, gangrene). | |||
*Arteriographic findings consistent with the disease. | |||
Exclusions - with lab tests:<ref name=pmid16722538/> | |||
*Autoimmune disease. | |||
*Hypercoagulable state. | |||
*[[Diabetes mellitus]]. | |||
*Radiographic findings suggestive of proximal emboli source (echocardiography, arteriography). | |||
==Gross== | ==Gross== | ||
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** Endarteritis - neutrophils at the internal elastic lamina (IEL). | ** Endarteritis - neutrophils at the internal elastic lamina (IEL). | ||
** Periarteritis - neutrophils around the arteries. | ** Periarteritis - neutrophils around the arteries. | ||
* | *Luminal narrowing due to thrombi.<ref name=pmid16722538/> | ||
**Organizing thrombi = thickened tunica intima. | |||
**Vessels may be re-canalized. | |||
Notes: | Notes: | ||
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==Sign out== | ==Sign out== | ||
<pre> | <pre> | ||
MIDDLE FINGER DISTAL | MIDDLE FINGER DISTAL PHALANX, LEFT, AMPUTATION: | ||
- | - ENDARTERITIS, PERIARTERITIS, INTRAVASCULAR THROMBI AND GANGRENE CONSISTENT WITH | ||
THROMBOANGIITIS OBLITERANS (BUERGER'S DISEASE). | |||
</pre> | </pre> | ||
Latest revision as of 16:24, 16 July 2013
Thromboangiitis obliterans, abbreviated TAO, is a rare vascular disease characterized by recurrent thrombosis. It primarily afflicts young smokers and is also known as Buerger disease.
It should not be confused with Berger disease (IgA nephropathy).
General
Typical symptoms/signs - progression:[3]
- Intermittent claudication -> ulcers -> gangrene -> amputation.
Treatment:
- Stop smoking.[3]
Formal clinical criteria
Simple
All of the following - as per Shionoya:[4]
- Smoking.
- No other atherosclerosis risk factors.
- Onset < 50 years old.
- Infrapopliteal arterial occlusions.
- Arm involvement or phlebitis migrans;
Complicated
All of the following - as per Olin:[5]
- Less than 45 years old.
- Current or recent tobacco use.
- Sign or symptoms of distal extremity ischemia (claudication, pain at rest, ulcers, gangrene).
- Arteriographic findings consistent with the disease.
Exclusions - with lab tests:[4]
- Autoimmune disease.
- Hypercoagulable state.
- Diabetes mellitus.
- Radiographic findings suggestive of proximal emboli source (echocardiography, arteriography).
Gross
- Afflicts small and medium-sized vessels of the extremities.
- Corkscrew vessels - seen on angiography.[2]
Microscopic
Features:[6]
- Acute inflammation:
- Endarteritis - neutrophils at the internal elastic lamina (IEL).
- Periarteritis - neutrophils around the arteries.
- Luminal narrowing due to thrombi.[4]
- Organizing thrombi = thickened tunica intima.
- Vessels may be re-canalized.
Notes:
- Typically segmental.[3]
DDx:
- Peripheral vascular disease (atherosclerosis) - typically lacks the acute inflammation around the IEL and around the vessels.
- Vasculitis - have fibrinoid necrosis.
Images:
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MIDDLE FINGER DISTAL PHALANX, LEFT, AMPUTATION: - ENDARTERITIS, PERIARTERITIS, INTRAVASCULAR THROMBI AND GANGRENE CONSISTENT WITH THROMBOANGIITIS OBLITERANS (BUERGER'S DISEASE).
See also
References
- ↑ Highlander, P.; Southerland, CC.; VonHerbulis, E.; Gonzalez, A. (Jan 2011). "Buerger disease (thromboangiitis obliterans): a clinical diagnosis.". Adv Skin Wound Care 24 (1): 15-7. doi:10.1097/01.ASW.0000392923.37852.43. PMID 21173586.
- ↑ 2.0 2.1 Fujii, Y.; Soga, J.; Nakamura, S.; Hidaka, T.; Hata, T.; Idei, N.; Fujimura, N.; Nishioka, K. et al. (Aug 2010). "Classification of corkscrew collaterals in thromboangiitis obliterans (Buerger's disease): relationship between corkscrew type and prevalence of ischemic ulcers.". Circ J 74 (8): 1684-8. PMID 20534945.
- ↑ 3.0 3.1 3.2 Dargon, PT.; Landry, GJ. (Aug 2012). "Buerger's disease.". Ann Vasc Surg 26 (6): 871-80. doi:10.1016/j.avsg.2011.11.005. PMID 22284771.
- ↑ 4.0 4.1 4.2 Arkkila, PE. (2006). "Thromboangiitis obliterans (Buerger's disease).". Orphanet J Rare Dis 1: 14. doi:10.1186/1750-1172-1-14. PMC 1523324. PMID 16722538. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1523324/.
- ↑ Olin, JW. (Sep 2000). "Thromboangiitis obliterans (Buerger's disease).". N Engl J Med 343 (12): 864-9. doi:10.1056/NEJM200009213431207. PMID 10995867.
- ↑ Kurata, A.; Schulz, A.; Franke, FE. (2004). "Reappraisal of thromboangiitis obliterans--a pathological contribution.". Verh Dtsch Ges Pathol 88: 231-6. PMID 16892557.