Difference between revisions of "Syphilis"

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'''Syphilis''' is the infectious disease caused by ''Treponema pallidum''.
'''Syphilis''' is the infectious disease caused by ''Treponema pallidum''.
==General==
*Classically affects the [[testis]] before the epididymis.<ref name=Ref_WMSP364>{{Ref WMSP|364}}</ref>
**[[Tuberculosis]]<ref name=pmid19468469>{{Cite journal  | last1 = Das | first1 = P. | last2 = Ahuja | first2 = A. | last3 = Gupta | first3 = SD. | title = Incidence, etiopathogenesis and pathological aspects of genitourinary tuberculosis in India: A journey revisited. | journal = Indian J Urol | volume = 24 | issue = 3 | pages = 356-61 | month = Jul | year = 2008 | doi = 10.4103/0970-1591.42618 | PMID = 19468469 }}</ref> and gonorrhea usually affect the epididymis before the testis.
*Considered one of the [[TORCH infections]].
==Gross==
Aorta:
*Wrinkled intimal surface - "tree bark" appearance.<ref>{{Ref AoGP|80}}</ref>


==Microscopic==
==Microscopic==
Features:
Features:
*Spirochetes - '''key feature'''.
*[[Plasma cells]] - '''key feature'''.<ref name=pmid18948765>{{Cite journal  | last1 = Brinster | first1 = NK. | title = Dermatopathology for the surgical pathologist: a pattern-based approach to the diagnosis of inflammatory skin disorders (part II). | journal = Adv Anat Pathol | volume = 15 | issue = 6 | pages = 350-69 | month = Nov | year = 2008 | doi = 10.1097/PAP.0b013e31818b1ac6 | PMID = 18948765 }}</ref>
*May form ''gumma'' (granulomas) in the tertiary phase.<ref>URL: [http://pediatrics.aappublications.org/cgi/content/full/104/1/e4 http://pediatrics.aappublications.org/cgi/content/full/104/1/e4]. Accessed on: 17 November 2010.</ref>
*Spirochetes - '''diagnostic'''.
*+/-[[Granulomas]]<ref name=Ref_PCPBoD8_47>{{Ref PCPBoD8|47}}</ref> - ''gumma'' - in the tertiary phase.<ref>URL: [http://pediatrics.aappublications.org/cgi/content/full/104/1/e4 http://pediatrics.aappublications.org/cgi/content/full/104/1/e4]. Accessed on: 17 November 2010.</ref>
 
DDx:
*[[Plasma cell neoplasm]].
*Reactive changes.
*[[Zoon balanitis]].
*Other spirochetes, e.g. ''Borrelia burgdorferi''.


Useful [[stains]]:
==[[Stains]]==
*Dieterle stain.
*[[Dieterle stain]].


Image: [http://en.wikipedia.org/wiki/File:Treponema_pallidum_-_very_high_mag_-_extreme_crop.jpg Dieterle stain - T. pallidum (WC)].
===Image===
<gallery>
Image:Treponema_pallidum_-_very_high_mag_-_extreme_crop.jpg | T. pallidum - very high mag. cropped. [[Dieterle stain]]. (WC)
Image:Treponema_pallidum_-_very_high_mag.jpg | T. pallidum - very high mag. [[Dieterle stain]]. (WC)
</gallery>


==See also==
==See also==
*[[Vascular disease]].
*[[Vascular disease]].
*[[Microorganisms]].
*[[Microorganisms]].
*[[Intestinal spirochetosis]].
*[[Inflammatory skin disorders]].
*[[Granulomatous orchitis]].


==References==
==References==
{{Reflist|1}}
{{Reflist|2}}


[[Category:Weird stuff]]
[[Category:Weird stuff]]
[[Category:Diagnosis]]

Latest revision as of 00:15, 26 March 2024

Syphilis is the infectious disease caused by Treponema pallidum.

General

Gross

Aorta:

  • Wrinkled intimal surface - "tree bark" appearance.[3]

Microscopic

Features:

DDx:

Stains

Image

See also

References

  1. Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 364. ISBN 978-0781765275.
  2. Das, P.; Ahuja, A.; Gupta, SD. (Jul 2008). "Incidence, etiopathogenesis and pathological aspects of genitourinary tuberculosis in India: A journey revisited.". Indian J Urol 24 (3): 356-61. doi:10.4103/0970-1591.42618. PMID 19468469.
  3. Rose, Alan G. (2008). Atlas of Gross Pathology with Histologic Correlation (1st ed.). Cambridge University Press. pp. 80. ISBN 978-0521868792.
  4. Brinster, NK. (Nov 2008). "Dermatopathology for the surgical pathologist: a pattern-based approach to the diagnosis of inflammatory skin disorders (part II).". Adv Anat Pathol 15 (6): 350-69. doi:10.1097/PAP.0b013e31818b1ac6. PMID 18948765.
  5. Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 47. ISBN 978-1416054542.
  6. URL: http://pediatrics.aappublications.org/cgi/content/full/104/1/e4. Accessed on: 17 November 2010.