Smoking-related interstitial fibrosis

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Smoking-related interstitial fibrosis, abbreviated SRIF, is a benign pauci-inflammatory scarring associated with smoking.

General

  • Associated with emphysema and respiratory bronchiolitis.[1]

Gross

  • Subpleural and centrilobular predominance.[1]

Microscopic

Features:[1]

  • Septal thickening of alveoli with:
    • Thick collagen bundles - may be described as "ropy".[2]
    • Hyperplastic smooth muscle fibres.
  • Minimal inflammation.

DDx:

Images

See also

References

  1. 1.0 1.1 1.2 Katzenstein, AL. (Jan 2012). "Smoking-related interstitial fibrosis (SRIF), pathogenesis and treatment of usual interstitial pneumonia (UIP), and transbronchial biopsy in UIP.". Mod Pathol 25 Suppl 1: S68-78. doi:10.1038/modpathol.2011.154. PMID 22214972.
  2. 2.0 2.1 Primiani, A.; Dias-Santagata, D.; Iafrate, AJ.; Kradin, RL. (2014). "Pulmonary adenocarcinoma mutation profile in smokers with smoking-related interstitial fibrosis.". Int J Chron Obstruct Pulmon Dis 9: 525-31. doi:10.2147/COPD.S61932. PMID 24920890.