Difference between revisions of "Sickle cell disease"

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[[Image:Renal_medullary_carcinoma_-_2_--_very_high_mag.jpg|thumb|Extravascular drepanocytes (sickled [[red blood cell]]s) in [[renal medullary carcinoma]]. [[H&E stain]].]]
'''Sickle cell disease''', also '''sickle cell [[anemia]]''', is a heritable [[haematopathology|haematologic]] disorder associated with serious pathologies.
'''Sickle cell disease''', also '''sickle cell [[anemia]]''', is a heritable [[haematopathology|haematologic]] disorder associated with serious pathologies.
==Red blood cells==
*Sickled red blood cells (drepanocytes).


==Liver==
==Liver==
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==Gallbladder==
==Gallbladder==
{{Main|Gallbladder}}
{{Main|Gallbladder}}
*Pigment stones.
*Pigment stones.  


==Kidney==
==Kidney==

Latest revision as of 13:42, 29 October 2021

Extravascular drepanocytes (sickled red blood cells) in renal medullary carcinoma. H&E stain.

Sickle cell disease, also sickle cell anemia, is a heritable haematologic disorder associated with serious pathologies.

Red blood cells

  • Sickled red blood cells (drepanocytes).

Liver

Images

Spleen

  • It may lead to auto infarction - result in hypofunction.
    • Splenectomy have increased risk from polysaccharide encapsulated bacteria, i.e. Neisseria meningitis, Haemophilus influenzae, and Streptococcus pneumoniae.

Gallbladder

  • Pigment stones.

Kidney

Femoral head

See also

References

  1. Hurtova, M.; Bachir, D.; Lee, K.; Calderaro, J.; Decaens, T.; Kluger, MD.; Zafrani, ES.; Cherqui, D. et al. (Apr 2011). "Transplantation for liver failure in patients with sickle cell disease: challenging but feasible.". Liver Transpl 17 (4): 381-92. doi:10.1002/lt.22257. PMID 21445921.
  2. 2.0 2.1 2.2 2.3 2.4 Davis CJ, Mostofi FK, Sesterhenn IA (January 1995). "Renal medullary carcinoma. The seventh sickle cell nephropathy". Am. J. Surg. Pathol. 19 (1): 1–11. PMID 7528470.