Difference between revisions of "Sickle cell disease"

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[[Image:Renal_medullary_carcinoma_-_2_--_very_high_mag.jpg|thumb|Extravascular drepanocytes (sickled [[red blood cell]]s) in [[renal medullary carcinoma]]. [[H&E stain]].]]
'''Sickle cell disease''', also '''sickle cell [[anemia]]''', is a heritable [[haematopathology|haematologic]] disorder associated with serious pathologies.
'''Sickle cell disease''', also '''sickle cell [[anemia]]''', is a heritable [[haematopathology|haematologic]] disorder associated with serious pathologies.
==Red blood cells==
*Sickled red blood cells (drepanocytes).


==Liver==
==Liver==
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*[[Cirrhosis]] and liver failure.<ref name=pmid21445921>{{Cite journal  | last1 = Hurtova | first1 = M. | last2 = Bachir | first2 = D. | last3 = Lee | first3 = K. | last4 = Calderaro | first4 = J. | last5 = Decaens | first5 = T. | last6 = Kluger | first6 = MD. | last7 = Zafrani | first7 = ES. | last8 = Cherqui | first8 = D. | last9 = Mallat | first9 = A. | title = Transplantation for liver failure in patients with sickle cell disease: challenging but feasible. | journal = Liver Transpl | volume = 17 | issue = 4 | pages = 381-92 | month = Apr | year = 2011 | doi = 10.1002/lt.22257 | PMID = 21445921 }}</ref>
*[[Cirrhosis]] and liver failure.<ref name=pmid21445921>{{Cite journal  | last1 = Hurtova | first1 = M. | last2 = Bachir | first2 = D. | last3 = Lee | first3 = K. | last4 = Calderaro | first4 = J. | last5 = Decaens | first5 = T. | last6 = Kluger | first6 = MD. | last7 = Zafrani | first7 = ES. | last8 = Cherqui | first8 = D. | last9 = Mallat | first9 = A. | title = Transplantation for liver failure in patients with sickle cell disease: challenging but feasible. | journal = Liver Transpl | volume = 17 | issue = 4 | pages = 381-92 | month = Apr | year = 2011 | doi = 10.1002/lt.22257 | PMID = 21445921 }}</ref>


Images:
===Images===
*[http://commons.wikimedia.org/wiki/File:Sickle_cell_disease_and_cirrhosis_-_intermed_mag.jpg Sickle cell disease and cirrhosis - intermed. mag. (WC)].
<gallery>
*[http://commons.wikimedia.org/wiki/File:Sickle_cell_disease_and_cirrhosis_-_very_high_mag.jpg Sickle cell disease and cirrhosis - very high mag. (WC)].
Image:Sickle_cell_disease_and_cirrhosis_-_intermed_mag.jpg | Sickle cell disease and cirrhosis - intermed. mag. (WC)
Image:Sickle_cell_disease_and_cirrhosis_-_high_mag.jpg | Sickle cell disease and cirrhosis - high mag. (WC)
Image:Sickle_cell_disease_and_cirrhosis_-_very_high_mag.jpg | Sickle cell disease and cirrhosis - very high mag. (WC)
</gallery>


==Spleen==
==Spleen==
{{Main|Spleen}}
{{Main|Spleen}}
*It may lead to auto infarction - result in hypofunction.
*It may lead to auto [[splenic infarction|infarction]] - result in hypofunction.
**Splenectomy have increased risk from ''polysaccharide encapsulated bacteria'', i.e. Neisseria meningitis, Haemophilus influenzae, and Streptococcus pneumoniae.
**Splenectomy have increased risk from ''polysaccharide encapsulated bacteria'', i.e. Neisseria meningitis, Haemophilus influenzae, and Streptococcus pneumoniae.


==Gallbladder==
==Gallbladder==
{{Main|Gallbladder}}
{{Main|Gallbladder}}
*Pigment stones.
*Pigment stones.  


==Kidney==
==Kidney==
*[[Renal medullary carcinoma]] associated with sickle cell trait (heterozygotes for the sickle cell allele).<ref name=pmid7528470>{{cite journal |author=Davis CJ, Mostofi FK, Sesterhenn IA |title=Renal medullary carcinoma. The seventh sickle cell nephropathy |journal=Am. J. Surg. Pathol. |volume=19 |issue=1 |pages=1–11 |year=1995 |month=January |pmid=7528470 |doi= |url=}}</ref>  
*[[Renal medullary carcinoma]] associated with sickle cell trait (heterozygotes for the sickle cell allele<ref name=pmid7528470>{{cite journal |author=Davis CJ, Mostofi FK, Sesterhenn IA |title=Renal medullary carcinoma. The seventh sickle cell nephropathy |journal=Am. J. Surg. Pathol. |volume=19 |issue=1 |pages=1–11 |year=1995 |month=January |pmid=7528470 |doi= |url=}}</ref>) or sickle cell disease.
*Papillary necrosis.<ref name=pmid7528470/>
*[[Nephrotic syndrome]].<ref name=pmid7528470/>
*Renal [[infarction]].<ref name=pmid7528470/>
*[[Pyelonephritis]].<ref name=pmid7528470/>
 
==Femoral head==
*[[Avascular necrosis of the femoral head]].


==See also==
==See also==

Latest revision as of 13:42, 29 October 2021

Extravascular drepanocytes (sickled red blood cells) in renal medullary carcinoma. H&E stain.

Sickle cell disease, also sickle cell anemia, is a heritable haematologic disorder associated with serious pathologies.

Red blood cells

  • Sickled red blood cells (drepanocytes).

Liver

Images

Spleen

  • It may lead to auto infarction - result in hypofunction.
    • Splenectomy have increased risk from polysaccharide encapsulated bacteria, i.e. Neisseria meningitis, Haemophilus influenzae, and Streptococcus pneumoniae.

Gallbladder

  • Pigment stones.

Kidney

Femoral head

See also

References

  1. Hurtova, M.; Bachir, D.; Lee, K.; Calderaro, J.; Decaens, T.; Kluger, MD.; Zafrani, ES.; Cherqui, D. et al. (Apr 2011). "Transplantation for liver failure in patients with sickle cell disease: challenging but feasible.". Liver Transpl 17 (4): 381-92. doi:10.1002/lt.22257. PMID 21445921.
  2. 2.0 2.1 2.2 2.3 2.4 Davis CJ, Mostofi FK, Sesterhenn IA (January 1995). "Renal medullary carcinoma. The seventh sickle cell nephropathy". Am. J. Surg. Pathol. 19 (1): 1–11. PMID 7528470.