Sarcomatoid urothelial carcinoma

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Sarcomatoid urothelial carcinoma
Diagnosis in short

Sarcomatoid urothelial carcinoma. H&E stain.
Subtypes (subtype of urothelial carcinoma)
LM DDx sarcoma, carcinosarcoma - esp. in women, other sarcomatoid carcinomas, collision tumour
IHC GATA3 +ve
Site urothelium - urinary bladder, ureter, renal pelvis

Prevalence very rare
Prognosis poor
Treatment resection if feasible

Sarcomatoid urothelial carcinoma (abbreviated sarcomatoid UC), also sarcomatoid urothelial cell carcinoma (abbreviated sarcomatoid UCC), is a rare variant of urothelial carcinoma.[1]

General

  • Rare[1] approximately 0.1% of bladder carcinomas - based on the SEER database in the time span 1973-2004.[2]
  • Aggressive >55% dead within one year of presentation.[1]

Gross

Microscopic

Features:

  1. Urothelial carcinoma (classic or recognizable variant).
  2. Sarcomatoid differentiation - typically (undifferentiated) spindle cells.

DDx:

Images

IHC

  • GATA3 +ve (16 +ve of 22 cases[5]).

See also

References

  1. 1.0 1.1 1.2 1.3 Fatima, N.; Canter, DJ.; Carthon, BC.; Kucuk, O.; Master, VA.; Nieh, PT.; Ogan, K.; Osunkoya, AO. (Jun 2015). "Sarcomatoid urothelial carcinoma of the bladder: a contemporary clinicopathologic analysis of 37 cases.". Can J Urol 22 (3): 7783-7. PMID 26068625.
  2. Wang, J.; Wang, FW.; Lagrange, CA.; Hemstreet Iii, GP.; Kessinger, A. (2010). "Clinical features of sarcomatoid carcinoma (carcinosarcoma) of the urinary bladder: analysis of 221 cases.". Sarcoma 2010. doi:10.1155/2010/454792. PMID 20706685.
  3. Nicolas, MM.; Nazarullah, A.; Guo, CC. (Apr 2014). "Sarcomatoid urothelial carcinoma with chondrosarcomatous differentiation of the ureter: a case report.". Anal Quant Cytopathol Histpathol 36 (2): 111-6. PMID 24902363.
  4. Tian, X.; Zhao, J.; Wang, Y.; Xing, N. (Sep 2014). "Sarcomatoid carcinoma of the renal pelvis: A case report.". Oncol Lett 8 (3): 1208-1210. doi:10.3892/ol.2014.2240. PMID 25120689.
  5. Fatima, N.; Osunkoya, AO. (Aug 2014). "GATA3 expression in sarcomatoid urothelial carcinoma of the bladder.". Hum Pathol 45 (8): 1625-9. doi:10.1016/j.humpath.2014.03.015. PMID 24824028.