Sarcomatoid carcinoma of the prostate

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Sarcomatoid carcinoma of the prostate
Diagnosis in short

Sarcomatoid carcinoma of the prostate. H&E stain.

Synonyms sarcomatoid prostatic carcinoma
Subtypes (subtype of prostate carcinoma)
LM DDx sarcoma, sarcomatoid urothelial carcinoma
IHC PSA +ve, keratin +ve
Grossing notes prostate biopsy, prostate chips, radical prostatectomy
Staging prostate cancer staging
Site prostate gland - see prostate carcinoma

Syndromes see prostate carcinoma

Clinical history typically have history of conventional prostate carcinoma
Prevalence uncommon
Prognosis poor
Clin. DDx see prostate carcinoma
Treatment see prostate carcinoma

Sarcomatoid carcinoma of the prostate, also sarcomatoid prostatic carcinoma, is a rare subtype of prostatic carcinoma with histomorphologic features suggestive of a sarcoma, and a poor prognosis.

General

  • Rare.[1]
  • Poor prognosis - estimated 20% mortality at one year.[1]

Microscopic

Features:[2]

  • Typically a biphasic tumour:
    1. Spindle cells (sarcomatous component).
    2. Epithelial (glandular) component (like conventional prostate carcinoma).
      • May be absent. ‡

Note:

  • ‡ The history is should be compelling or the tumour keratin positive, if no epithelial component is present.

DDx:

Images

Sarcomatoid carcinoma:

Accompanying (conventional) prostatic carcinoma:

IHC

Features - typical:[2]

  • PSA +ve.
  • Keratin +ve.

See also

References

  1. 1.0 1.1 Hansel, DE.; Epstein, JI. (Oct 2006). "Sarcomatoid carcinoma of the prostate: a study of 42 cases.". Am J Surg Pathol 30 (10): 1316-21. doi:10.1097/01.pas.0000209838.92842.bf. PMID 17001164.
  2. 2.0 2.1 Zhou, Ming; Magi-Galluzzi, Cristina (2006). Genitourinary Pathology: A Volume in Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 77 & 80. ISBN 978-0443066771.