Difference between revisions of "Reactive changes"
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*Neoplastic processes. | *Neoplastic processes. | ||
The line between a reactive process and a neoplastic process may be fuzzy. In the context of inflammation, nuclear changes are typically present and the threshold for calling suspicious or malignancy is typically higher. | Significance of nuclear changes in inflammation: | ||
*The line between a reactive process and a neoplastic process may be fuzzy. | |||
Consequence: | |||
*In the context of inflammation, nuclear changes are typically present and the threshold for calling suspicious or malignancy is typically higher. | |||
==Microscopic== | ==Microscopic== | ||
Revision as of 07:05, 31 December 2014
Reactive changes is a commonly used term that implies:
- Inflammation.
- Nuclear changes compatible with inflammation.
General
Nuclear changes are seen in:
- Inflammatory processes.
- Repair.
- Neoplastic processes.
Significance of nuclear changes in inflammation:
- The line between a reactive process and a neoplastic process may be fuzzy.
Consequence:
- In the context of inflammation, nuclear changes are typically present and the threshold for calling suspicious or malignancy is typically higher.
Microscopic
Features - generic:
- Nuclear changes:
- Nuclear enlargement.
- Nuclear hyperchromasia.
- Prominent nucleoli.
- Inflammation - acute and/or chronic.
DDx:
- Waffle diagnosis (e.g. indefinite for dysplasia) - nuclear changes of unknown significance.
- Terminology dependent on the anatomical site.
- Nuclear atypia.
- This is often qualified as it may represent neoplastic process or a benign process dependent on the context.
- Common qualifiers:
- Worrisome lesions: "cannot exclude dysplasia", "suspicious for malignancy".
- Suspected to be benign: "favour benign".
- Malignancy.