48,470
edits
Difference between revisions of "Neurodegenerative diseases"
Jump to navigation
Jump to search
Neurodegenerative diseases (view source)
Revision as of 16:56, 12 November 2010
, 16:56, 12 November 2010→Overview: table, disease, clinical
m (overview) |
(→Overview: table, disease, clinical) |
||
| Line 10: | Line 10: | ||
{{familytree | B01 | | B02 | | B03 | | B04 | |B01=Amyloidoses|B02=Tauopathies|B03=α-synucleinopathies|B04=TDP-43}} | {{familytree | B01 | | B02 | | B03 | | B04 | |B01=Amyloidoses|B02=Tauopathies|B03=α-synucleinopathies|B04=TDP-43}} | ||
{{familytree/end}} | {{familytree/end}} | ||
===Common diseases=== | |||
[[Amyloid]]oses: | |||
*Alzheimer disease (Abeta). | |||
*Creutzfeldt-Jakob disease (PrP). | |||
Taupathies: | |||
*Progressive supranuclear palsy. | |||
*Pick's disease. | |||
Synucleinopathies: | |||
*Parkinson disease. | |||
*Dementia with Lewy bodies. | |||
*Multiple system atrophy. | |||
TDP-43 proteinopathies: | |||
*Amyotrophic alteral sclerosis. | |||
*Frontotemporal lobar degeneration with ubiquitinated inclusions. | |||
====Table=== | |||
Disease/pathology/clinical correlation based on ''Dickson'':<ref name=pmid19918325>{{cite journal |author=Dickson DW |title=Neuropathology of non-Alzheimer degenerative disorders |journal=Int J Clin Exp Pathol |volume=3 |issue=1 |pages=1–23 |year=2009 |pmid=19918325 |pmc=2776269 |doi= |url=http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776269/?tool=pubmed}}</ref> | |||
{| class="wikitable sortable" style="margin-left:auto;margin-right:auto" | |||
| '''Disease''' | |||
| '''Mutated protein''' | |||
| '''Distribution''' | |||
| '''Clinical''' | |||
| '''Image''' | |||
|- | |||
| Alzheimer disease | |||
| Abeta (mutated ''APP'') | |||
| corticolimbic | |||
| dementia | |||
| Image? | |||
|- | |||
| Creutzfeldt-Jakob disease | |||
| PrP<sup>res</sup> | |||
| cortical & basal ganglia | |||
| rapid progression dementia, <br>movement disorder | |||
| Image? | |||
|- | |||
| Progressive supranuclear palsy | |||
| tau 4R | |||
| basal ganglia, brainstem | |||
| parkinsonism | |||
| Image? | |||
|- | |||
| Pick disease | |||
| tau 3R | |||
| corticolimbic | |||
| dementia + focal <br>cortical syndrome | |||
| Image? | |||
|- | |||
| Parkinson disease | |||
| alpha-synuclein | |||
| brainstem | |||
| parkinsonism | |||
| Image? | |||
|- | |||
| Dementia with Lewy bodies | |||
| alpha-synuclein | |||
| corticolimbic, brainstem | |||
| dementia + parkinsonism | |||
| Image? | |||
|- | |||
| Multiple system atrophy | |||
| alpha-synuclein | |||
| basal ganglia, brainstem, cerebellum | |||
| ataxia, parkinsonism | |||
| Image | |||
|- | |||
| Amyotrophic lateral sclerosis | |||
| TDP-43 | |||
| motor neurons | |||
| spasticity, weakness | |||
| Image | |||
|- | |||
| Frontotemporal lobar degeneration with ubiquitinated inclusions | |||
| TDP-43 | |||
| cortex, basal ganglia | |||
| dementia, focal cortical syndromes | |||
| Image? | |||
|- <!-- | |||
| Disease | |||
| Mutated protein | |||
| Distribution | |||
| Clinical | |||
| Image --> | |||
|} | |||
==IHC== | |||
*AT-8 = stains phosphorylated tau.<ref name=pmid19946779>{{cite journal |author=Seelaar H, Klijnsma KY, de Koning I, ''et al.'' |title=Frequency of ubiquitin and FUS-positive, TDP-43-negative frontotemporal lobar degeneration |journal=J. Neurol. |volume=257 |issue=5 |pages=747–53 |year=2010 |month=May |pmid=19946779 |pmc=2864899 |doi=10.1007/s00415-009-5404-z |url=http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864899/}}</ref> | |||
*p62; poli-ubiquitin-binding protein p62.<ref name=pmid19946779/> | |||
*TDP-43. | |||
==General DDx of dementia== | ==General DDx of dementia== | ||