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Difference between revisions of "Neurodegenerative diseases"
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Neurodegenerative diseases (view source)
Revision as of 17:12, 12 November 2010
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*Frontotemporal lobar degeneration with ubiquitinated inclusions. | *Frontotemporal lobar degeneration with ubiquitinated inclusions. | ||
====Table=== | ====Table==== | ||
Disease/pathology/clinical correlation based on ''Dickson'':<ref name=pmid19918325>{{cite journal |author=Dickson DW |title=Neuropathology of non-Alzheimer degenerative disorders |journal=Int J Clin Exp Pathol |volume=3 |issue=1 |pages=1–23 |year=2009 |pmid=19918325 |pmc=2776269 |doi= |url=http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776269/?tool=pubmed}}</ref> | Disease/pathology/clinical correlation based on ''Dickson'':<ref name=pmid19918325>{{cite journal |author=Dickson DW |title=Neuropathology of non-Alzheimer degenerative disorders |journal=Int J Clin Exp Pathol |volume=3 |issue=1 |pages=1–23 |year=2009 |pmid=19918325 |pmc=2776269 |doi= |url=http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776269/?tool=pubmed}}</ref> | ||
{| class="wikitable sortable" style="margin-left:auto;margin-right:auto" | {| class="wikitable sortable" style="margin-left:auto;margin-right:auto" | ||
| Line 40: | Line 40: | ||
| Alzheimer disease | | Alzheimer disease | ||
| Abeta (mutated ''APP'') | | Abeta (mutated ''APP'') | ||
| corticolimbic | | corticolimbic, usu. <br>spares occipital | ||
| dementia | | dementia | ||
| Image? | | Image? | ||
|- | |- | ||
| Creutzfeldt-Jakob disease | | Creutzfeldt-Jakob disease | ||
| PrP<sup>res</sup> | | PrP<sup>res</sup> (mutated PrP) | ||
| cortical & basal ganglia | | cortical & basal ganglia | ||
| rapid progression | | dementia (rapid progression), <br>movement disorder | ||
| Image? | | Image? | ||
|- | |- | ||
| Line 68: | Line 68: | ||
| Image? | | Image? | ||
|- | |- | ||
| Dementia with Lewy bodies | | Dementia with <br>Lewy bodies | ||
| alpha-synuclein | | alpha-synuclein | ||
| corticolimbic, brainstem | | corticolimbic, brainstem | ||
| Line 77: | Line 77: | ||
| alpha-synuclein | | alpha-synuclein | ||
| basal ganglia, brainstem, cerebellum | | basal ganglia, brainstem, cerebellum | ||
| ataxia | | parkinsonism, ataxia | ||
| Image | | Image | ||
|- | |- | ||
| Amyotrophic lateral sclerosis | | Amyotrophic lateral <br>sclerosis (ALS) | ||
| TDP-43 | | TDP-43 | ||
| motor neurons | | motor neurons | ||
| Line 86: | Line 86: | ||
| Image | | Image | ||
|- | |- | ||
| Frontotemporal lobar degeneration with ubiquitinated inclusions | | Frontotemporal lobar <br>degeneration with <br>ubiquitinated inclusions | ||
| TDP-43 | | TDP-43 | ||
| cortex, basal ganglia | | cortex, basal ganglia | ||