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Difference between revisions of "Microsatellite instability in colorectal cancer"
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Microsatellite instability in colorectal cancer (view source)
Revision as of 21:09, 13 March 2016
, 21:09, 13 March 2016→IHC interpretation
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*'''Loss of nuclear staining''' in nuclei of the tumour ''implies'' a mutation. | *'''Loss of nuclear staining''' in nuclei of the tumour ''implies'' a mutation. | ||
**Nuclear staining = normal. | **Nuclear staining = normal. | ||
*Heterogenous MSH6 loss of staining is significant.<ref name=pmid26099011>{{Cite journal | last1 = Graham | first1 = RP. | last2 = Kerr | first2 = SE. | last3 = Butz | first3 = ML. | last4 = Thibodeau | first4 = SN. | last5 = Halling | first5 = KC. | last6 = Smyrk | first6 = TC. | last7 = Dina | first7 = MA. | last8 = Waugh | first8 = VM. | last9 = Rumilla | first9 = KM. | title = Heterogenous MSH6 loss is a result of microsatellite instability within MSH6 and occurs in sporadic and hereditary colorectal and endometrial carcinomas. | journal = Am J Surg Pathol | volume = 39 | issue = 10 | pages = 1370-6 | month = Oct | year = 2015 | doi = 10.1097/PAS.0000000000000459 | PMID = 26099011 }}</ref> | **Heterogenous MSH6 loss of staining is significant.<ref name=pmid26099011>{{Cite journal | last1 = Graham | first1 = RP. | last2 = Kerr | first2 = SE. | last3 = Butz | first3 = ML. | last4 = Thibodeau | first4 = SN. | last5 = Halling | first5 = KC. | last6 = Smyrk | first6 = TC. | last7 = Dina | first7 = MA. | last8 = Waugh | first8 = VM. | last9 = Rumilla | first9 = KM. | title = Heterogenous MSH6 loss is a result of microsatellite instability within MSH6 and occurs in sporadic and hereditary colorectal and endometrial carcinomas. | journal = Am J Surg Pathol | volume = 39 | issue = 10 | pages = 1370-6 | month = Oct | year = 2015 | doi = 10.1097/PAS.0000000000000459 | PMID = 26099011 }}</ref> | ||
MSI staining loss patterns:<ref name=pmid20632815/> | MSI staining loss patterns:<ref name=pmid20632815/> | ||