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Difference between revisions of "Microsatellite instability in colorectal cancer"
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Microsatellite instability in colorectal cancer (view source)
Revision as of 14:06, 7 March 2016
, 14:06, 7 March 2016→IHC
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*MSI testing (in the context of suspect [[Lynch syndrome]]) can be done on adenomatous polyps;<ref name=pmid>{{Cite journal | last1 = Pino | first1 = MS. | last2 = Mino-Kenudson | first2 = M. | last3 = Wildemore | first3 = BM. | last4 = Ganguly | first4 = A. | last5 = Batten | first5 = J. | last6 = Sperduti | first6 = I. | last7 = Iafrate | first7 = AJ. | last8 = Chung | first8 = DC. | title = Deficient DNA mismatch repair is common in Lynch syndrome-associated colorectal adenomas. | journal = J Mol Diagn | volume = 11 | issue = 3 | pages = 238-47 | month = May | year = 2009 | doi = 10.2353/jmoldx.2009.080142 | PMID = 19324997 }}</ref> however, dysplasia should be present.<ref name=pmid15220357>{{Cite journal | last1 = Higuchi | first1 = T. | last2 = Jass | first2 = JR. | title = My approach to serrated polyps of the colorectum. | journal = J Clin Pathol | volume = 57 | issue = 7 | pages = 682-6 | month = Jul | year = 2004 | doi = 10.1136/jcp.2003.015230 | PMID = 15220357 }}</ref> | *MSI testing (in the context of suspect [[Lynch syndrome]]) can be done on adenomatous polyps;<ref name=pmid>{{Cite journal | last1 = Pino | first1 = MS. | last2 = Mino-Kenudson | first2 = M. | last3 = Wildemore | first3 = BM. | last4 = Ganguly | first4 = A. | last5 = Batten | first5 = J. | last6 = Sperduti | first6 = I. | last7 = Iafrate | first7 = AJ. | last8 = Chung | first8 = DC. | title = Deficient DNA mismatch repair is common in Lynch syndrome-associated colorectal adenomas. | journal = J Mol Diagn | volume = 11 | issue = 3 | pages = 238-47 | month = May | year = 2009 | doi = 10.2353/jmoldx.2009.080142 | PMID = 19324997 }}</ref> however, dysplasia should be present.<ref name=pmid15220357>{{Cite journal | last1 = Higuchi | first1 = T. | last2 = Jass | first2 = JR. | title = My approach to serrated polyps of the colorectum. | journal = J Clin Pathol | volume = 57 | issue = 7 | pages = 682-6 | month = Jul | year = 2004 | doi = 10.1136/jcp.2003.015230 | PMID = 15220357 }}</ref> | ||
**''Sessile serrated adenomas without dysplasia'' should '''not''' be tested. | |||
===IHC interpretation=== | ===IHC interpretation=== | ||