Difference between revisions of "Micropapillary urothelial carcinoma"
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| Other = | | Other = | ||
| ClinDDx = | | ClinDDx = | ||
| Tx = | | Tx = cystectomy/cytoprostatectomy - advocated for cT1 disease by some | ||
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'''Micropapillary urothelial carcinoma''' (abbreviated '''MPUC'''), also '''micropapillary urothelial cell carcinoma''' (abbreviated '''MPUCC'''), is an aggressive variant of [[urothelial carcinoma]].<ref name=pmid21080874>{{Cite journal | last1 = Compérat | first1 = E. | last2 = Roupret | first2 = M. | last3 = Yaxley | first3 = J. | last4 = Reynolds | first4 = J. | last5 = Varinot | first5 = J. | last6 = Ouzaïd | first6 = I. | last7 = Cussenot | first7 = O. | last8 = Samaratunga | first8 = H. | title = Micropapillary urothelial carcinoma of the urinary bladder: a clinicopathological analysis of 72 cases. | journal = Pathology | volume = 42 | issue = 7 | pages = 650-4 | month = Dec | year = 2010 | doi = 10.3109/00313025.2010.522173 | PMID = 21080874 }}</ref> | '''Micropapillary urothelial carcinoma''' (abbreviated '''MPUC'''), also '''micropapillary urothelial cell carcinoma''' (abbreviated '''MPUCC'''), is an aggressive variant of [[urothelial carcinoma]].<ref name=pmid21080874>{{Cite journal | last1 = Compérat | first1 = E. | last2 = Roupret | first2 = M. | last3 = Yaxley | first3 = J. | last4 = Reynolds | first4 = J. | last5 = Varinot | first5 = J. | last6 = Ouzaïd | first6 = I. | last7 = Cussenot | first7 = O. | last8 = Samaratunga | first8 = H. | title = Micropapillary urothelial carcinoma of the urinary bladder: a clinicopathological analysis of 72 cases. | journal = Pathology | volume = 42 | issue = 7 | pages = 650-4 | month = Dec | year = 2010 | doi = 10.3109/00313025.2010.522173 | PMID = 21080874 }}</ref> | ||
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*Aggressive behaviour.<ref name=pmid21080874/> | *Aggressive behaviour.<ref name=pmid21080874/> | ||
*Typically presents with [[hematuria]].<ref name=pmid25673582>{{Cite journal | last1 = Chatterjee | first1 = D. | last2 = Das | first2 = A. | last3 = Radotra | first3 = BD. | title = Invasive micropapillary carcinoma of urinary bladder: a clinicopathological study. | journal = Indian J Pathol Microbiol | volume = 58 | issue = 1 | pages = 2-6 | month = | year = | doi = 10.4103/0377-4929.151153 | PMID = 25673582 }}</ref> | *Typically presents with [[hematuria]].<ref name=pmid25673582>{{Cite journal | last1 = Chatterjee | first1 = D. | last2 = Das | first2 = A. | last3 = Radotra | first3 = BD. | title = Invasive micropapillary carcinoma of urinary bladder: a clinicopathological study. | journal = Indian J Pathol Microbiol | volume = 58 | issue = 1 | pages = 2-6 | month = | year = | doi = 10.4103/0377-4929.151153 | PMID = 25673582 }}</ref> | ||
Treatment: | |||
*cT1 disease treated by radical cystectomy in some centres.<ref name=pmid25254936>{{Cite journal | last1 = Willis | first1 = DL. | last2 = Fernandez | first2 = MI. | last3 = Dickstein | first3 = RJ. | last4 = Parikh | first4 = S. | last5 = Shah | first5 = JB. | last6 = Pisters | first6 = LL. | last7 = Guo | first7 = CC. | last8 = Henderson | first8 = S. | last9 = Czerniak | first9 = BA. | title = Clinical outcomes of cT1 micropapillary bladder cancer. | journal = J Urol | volume = 193 | issue = 4 | pages = 1129-34 | month = Apr | year = 2015 | doi = 10.1016/j.juro.2014.09.092 | PMID = 25254936 }}</ref> | |||
==Microscopic== | ==Microscopic== | ||
Revision as of 02:52, 28 January 2016
| Micropapillary urothelial carcinoma | |
|---|---|
| Diagnosis in short | |
 Urothelial carcinoma with micropapillary features. H&E stain. | |
| Subtypes | (subtype of urothelial carcinoma) |
| LM DDx | conventional urothelial carcinoma, other micropapillary carcinomas (metastases) |
| IHC | CK7 +ve, CK20 +ve/-ve, GATA3 +ve, p63 -ve/+ve |
| Grossing notes | radical cystectomy grossing, cystoprostatectomy grossing, nephroureterectomy grossing |
| Staging | bladder cancer staging |
| Site | urothelium - urinary bladder, ureter, renal pelvis, urethra (males) |
|
| |
| Signs | hematuria (typical presentation) |
| Prevalence | rare |
| Prognosis | poor (aggressive course) |
| Treatment | cystectomy/cytoprostatectomy - advocated for cT1 disease by some |
Micropapillary urothelial carcinoma (abbreviated MPUC), also micropapillary urothelial cell carcinoma (abbreviated MPUCC), is an aggressive variant of urothelial carcinoma.[1]
General
Treatment:
- cT1 disease treated by radical cystectomy in some centres.[3]
Microscopic
Features:[1]
- Micropapillae - definitional.
- Nipple-like structures without fibrovascular cores.
- Quantity of micropapillary pattern (percentage) is variable.[2]
- Conventional urothelial carcinoma (typical).
DDx:
- Metastasis (breast, ovary, lung, pancreas, salivary gland).
Images
Case 1
UCCMPF - low mag.
UCCMPF - low mag.
UCCMPF - intermed. mag.
UCCMPF - high mag.
UCCMPF - high mag.
UCCMPF - very high mag.
Case 2
MPUC - low mag.
MPUC - intermed. mag.
MPUC - intermed. mag.
MPUC - high mag.
MPUC - high mag.
www
IHC
Features:
Others:[4]
- p63 -ve/+ve.
- p40 -ve/+ve.
Sign out
- Report percentage of micropapillary pattern - suggested.[citation needed]
See also
References
- ↑ 1.0 1.1 1.2 Compérat, E.; Roupret, M.; Yaxley, J.; Reynolds, J.; Varinot, J.; Ouzaïd, I.; Cussenot, O.; Samaratunga, H. (Dec 2010). "Micropapillary urothelial carcinoma of the urinary bladder: a clinicopathological analysis of 72 cases.". Pathology 42 (7): 650-4. doi:10.3109/00313025.2010.522173. PMID 21080874.
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Chatterjee, D.; Das, A.; Radotra, BD.. "Invasive micropapillary carcinoma of urinary bladder: a clinicopathological study.". Indian J Pathol Microbiol 58 (1): 2-6. doi:10.4103/0377-4929.151153. PMID 25673582.
- ↑ Willis, DL.; Fernandez, MI.; Dickstein, RJ.; Parikh, S.; Shah, JB.; Pisters, LL.; Guo, CC.; Henderson, S. et al. (Apr 2015). "Clinical outcomes of cT1 micropapillary bladder cancer.". J Urol 193 (4): 1129-34. doi:10.1016/j.juro.2014.09.092. PMID 25254936.
- ↑ 4.0 4.1 Lin, X.; Zhu, B.; Villa, C.; Zhong, M.; Kundu, S.; Rohan, SM.; Yang, XJ. (Sep 2014). "The utility of p63, p40, and GATA-binding protein 3 immunohistochemistry in diagnosing micropapillary urothelial carcinoma.". Hum Pathol 45 (9): 1824-9. doi:10.1016/j.humpath.2014.04.015. PMID 24993315.