Difference between revisions of "Mammary myofibroblastoma"

From Libre Pathology
Jump to navigation Jump to search
Line 7: Line 7:
| Micro      = well-circumscribed lesion, wpindle cells without nuclear atypia arranged in fascicles, interspersed thick bundles of collagen.
| Micro      = well-circumscribed lesion, wpindle cells without nuclear atypia arranged in fascicles, interspersed thick bundles of collagen.
| Subtypes  =
| Subtypes  =
| LMDDx      = [[metaplastic breast carcinoma]], [[fibromatosis]], [[leiomyoma]] of the breast, [[nodular fasciitis]], [[phyllodes tumour]]
| LMDDx      = [[metaplastic breast carcinoma]], [[fibromatosis]], [[leiomyoma]] of the breast, [[nodular fasciitis]], [[phyllodes tumour]], [[spindle cell lipoma]]
| Stains    =  
| Stains    =  
| IHC        = CD34 +ve, desmin +ve, H-caldesmon +ve, actin +ve, vimentin +ve, S100 -ve, beta-catenin -ve
| IHC        = CD34 +ve, desmin +ve, H-caldesmon +ve, actin +ve, vimentin +ve, S100 -ve, beta-catenin -ve

Revision as of 04:09, 16 February 2014

Mammary myofibroblastoma
Diagnosis in short

Mammary myofibroblastoma. H&E stain.

LM well-circumscribed lesion, wpindle cells without nuclear atypia arranged in fascicles, interspersed thick bundles of collagen.
LM DDx metaplastic breast carcinoma, fibromatosis, leiomyoma of the breast, nodular fasciitis, phyllodes tumour, spindle cell lipoma
IHC CD34 +ve, desmin +ve, H-caldesmon +ve, actin +ve, vimentin +ve, S100 -ve, beta-catenin -ve
Site breast

Clinical history postmenopausal female or older male
Prevalence rare
Prognosis benign
Treatment excision

Mammary myofibroblastoma is a rare benign pathology of the breast.

General

  • Rare.
  • Excision = cure.
  • Postmenopausal females and older males.[1][2]

Note:

  • In extra-mammary sites the tumour is known as a mammary-type myofibroblastoma may immunohistochemically and histomorphologically overlap with spindle cell lipoma.[3]

Microscopic

Features:[4]

  • Well-circumscribed lesion.
  • Spindle cells without nuclear atypia arranged in fascicles.
  • Interspersed thick bundles of collagen.

Notes:

  • No calcifications.
  • No necrosis.
  • No hemorrhage.

DDx:

Images

www:

IHC

Features:[2]

  • CD34 +ve.[3]
  • Desmin +ve.[3]
  • H-caldesmon +ve.
  • Actin +ve.
  • Vimentin +ve.

Other

  • S100 -ve.
  • Beta-catenin -ve. (???)

See also

References

  1. Qureshi, A.; Kayani, N.. "Myofibroblastoma of breast.". Indian J Pathol Microbiol 51 (3): 395-6. PMID 18723968.
  2. 2.0 2.1 Mele, M.; Jensen, V.; Wronecki, A.; Lelkaitis, G. (2011). "Myofibroblastoma of the breast: Case report and literature review.". Int J Surg Case Rep 2 (6): 93-6. doi:10.1016/j.ijscr.2011.02.006. PMC 3199680. PMID 22096693. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199680/. Cite error: Invalid <ref> tag; name "pmid22096693" defined multiple times with different content
  3. 3.0 3.1 3.2 McMenamin, ME.; Fletcher, CD. (Aug 2001). "Mammary-type myofibroblastoma of soft tissue: a tumor closely related to spindle cell lipoma.". Am J Surg Pathol 25 (8): 1022-9. PMID 11474286.
  4. O'Malley, Frances P.; Pinder, Sarah E. (2006). Breast Pathology: A Volume in Foundations in Diagnostic Pathology series (1st ed.). Churchill Livingstone. pp. 131. ISBN 978-0443066801.